Universidad Peruana Cayetano Heredia

Sub-maximal aerobic exercise training reduces haematocrit and ameliorates symptoms in Andean highlanders with chronic mountain sickness

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dc.contributor.author Macarlupú, J.L.
dc.contributor.author Vizcardo-Galindo, G.
dc.contributor.author Figueroa-Mujíca, R.
dc.contributor.author Voituron, N.
dc.contributor.author Richalet, J.-P.
dc.contributor.author Villafuerte, Francisco C.
dc.date.accessioned 2021-12-12T20:24:53Z
dc.date.available 2021-12-12T20:24:53Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/10190
dc.description.abstract New Findings: What is the central question of this study? What is the effect of sub-maximal aerobic exercise training on signs and symptoms of chronic mountain sickness (CMS) in Andean highlanders? What is the main finding and its importance? Aerobic exercise training (ET) effectively reduces haematocrit, ameliorates symptoms and improves aerobic capacity in CMS patients, suggesting that a regular aerobic ET programme might be used as a low-cost non-invasive/non-pharmacological management strategy of this syndrome. Abstract: Excessive erythrocytosis is the hallmark sign of chronic mountain sickness (CMS), a debilitating syndrome associated with neurological symptoms and increased cardiovascular risk. We have shown that unlike sedentary residents at the same altitude, trained individuals maintain haematocrit within sea-level range, and thus we hypothesise that aerobic exercise training (ET) might reduce excessive haematocrit and ameliorate CMS signs and symptoms. Eight highlander men (38 ± 12 years) with CMS (haematocrit: 70.6 ± 1.9%, CMS score: 8.8 ± 1.4) from Cerro de Pasco, Peru (4340 m) participated in the study. Baseline assessment included haematocrit, CMS score, pulse oximetry, maximal cardiopulmonary exercise testing and in-office plus 24 h ambulatory blood pressure (BP) monitoring. Blood samples were collected to assess cardiometabolic, erythropoietic, and haemolysis markers. ET consisted of pedalling exercise in a cycloergometer at 60% of (Formula presented.) for 1 h/day, 4 days/week for 8 weeks, and participants were assessed at weeks 4 and 8. Haematocrit and CMS score decreased significantly by week 8 (to 65.6 ± 6.6%, and 3.5 ± 0.8, respectively, P < 0.05), while (Formula presented.) and maximum workload increased with ET (33.8 ± 2.4 vs. 37.2 ± 2.0 ml/min/kg, P < 0.05; and 172.5 ± 9.4 vs. 210.0 ± 27.8 W, P < 0.01; respectively). Except for an increase in high-density lipoprotein cholesterol, other blood markers and BP showed no differences. Our results suggest that reduction of haematocrit and CMS symptoms results mainly from haemodilution due to plasma volume expansion rather than to haemolysis. In conclusion, we show that ET can effectively reduce haematocrit, ameliorate symptoms and improve aerobic capacity in CMS patients, suggesting that regular aerobic exercise might be used as a low-cost non-invasive and non-pharmacological management strategy en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Experimental Physiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adult en_US
dc.subject aerobic capacity en_US
dc.subject aerobic exercise en_US
dc.subject Andean highlanders en_US
dc.subject Article en_US
dc.subject blood pressure monitoring en_US
dc.subject cardiopulmonary exercise test en_US
dc.subject chronic mountain sickness en_US
dc.subject clinical article en_US
dc.subject erythrocytosis en_US
dc.subject excessive erythrocytosis en_US
dc.subject exercise training en_US
dc.subject hematocrit en_US
dc.subject hemodilution en_US
dc.subject hemolysis en_US
dc.subject high altitude en_US
dc.subject high density lipoprotein cholesterol en_US
dc.subject human en_US
dc.subject male en_US
dc.subject Monge´s disease en_US
dc.subject peak oxygen uptake en_US
dc.subject Peruvian en_US
dc.subject plasma volume en_US
dc.subject pulse oximetry en_US
dc.title Sub-maximal aerobic exercise training reduces haematocrit and ameliorates symptoms in Andean highlanders with chronic mountain sickness en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1113/EP089975
dc.relation.issn 1469-445X


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