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Hydroxychloroquine / azithromycin in COVID-19: The association between time to treatment and case fatality rate

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dc.contributor.author Accinelli Tanaka, Roberto Alfonso
dc.contributor.author Ynga-Meléndez, G.J.
dc.contributor.author Leon-Abarca, Juan Alonso
dc.contributor.author Lopez Oropeza, Lidia Marianella
dc.contributor.author Madrid-Cisneros, J.C.
dc.contributor.author Mendoza-Saldaña, J.D.
dc.date.accessioned 2021-12-12T20:24:54Z
dc.date.available 2021-12-12T20:24:54Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/10201
dc.description.abstract Background: Currently, there is no formally accepted pharmacological treatment for COVID-19. Materials and methods: We included COVID-19 outpatients of a Peruvian primary care center from Lima, Peru, who were treated between April 30 - September 30, 2020, with hydroxychloroquine and azithromycin. Logistic regression was applied to determine factors associated with case-fatality rate. Results: A total of 1265 COVID-19 patients with an average age of 44.5 years were studied. Women represented 50.1% of patients, with an overall 5.9 symptom days, SpO2 97%, temperature of 37.3 °C, 41% with at least one comorbidity and 96.1% one symptom or sign. No patient treated within the first 72 h of illness died. The factors associated with higher case fatality rate were age (OR = 1.06; 95% CI 1.01–1.11, p = 0.021), SpO2 (OR = 0.87; 95% CI 0.79–0.96, p = 0.005) and treatment onset (OR = 1.16; 95% CI 1.06–1.27, p = 0.002), being the latter the only associated in the multivariate analysis (OR = 1.18; 95% CI 1.05–1.32, p = 0.005). 0.6% of our patients died. Conclusions: The case fatality rate in COVID-19 outpatients treated with hydroxychloroquine/azithromycin was associated with the number of days of illness on which treatment was started en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Travel Medicine and Infectious Disease
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject abdominal pain en_US
dc.subject adult en_US
dc.subject aged en_US
dc.subject ageusia en_US
dc.subject anosmia en_US
dc.subject arthralgia en_US
dc.subject Article en_US
dc.subject azithromycin en_US
dc.subject Azithromycin en_US
dc.subject backache en_US
dc.subject body temperature en_US
dc.subject case fatality rate en_US
dc.subject child en_US
dc.subject chill en_US
dc.subject clinical feature en_US
dc.subject comorbidity en_US
dc.subject coronavirus disease 2019 en_US
dc.subject coughing en_US
dc.subject COVID-19 en_US
dc.subject decreased appetite en_US
dc.subject diarrhea en_US
dc.subject disease duration en_US
dc.subject dizziness en_US
dc.subject drug withdrawal en_US
dc.subject dyspnea en_US
dc.subject eye redness en_US
dc.subject female en_US
dc.subject fever en_US
dc.subject headache en_US
dc.subject human en_US
dc.subject hydroxychloroquine en_US
dc.subject Hydroxychloroquine en_US
dc.subject infant en_US
dc.subject irritability en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject Mortality en_US
dc.subject myalgia en_US
dc.subject nausea en_US
dc.subject newborn en_US
dc.subject nose obstruction en_US
dc.subject outpatient care en_US
dc.subject pain en_US
dc.subject Peru en_US
dc.subject Peruvian en_US
dc.subject primary medical care en_US
dc.subject rash en_US
dc.subject SARS-CoV-2 en_US
dc.subject sore throat en_US
dc.subject thorax pain en_US
dc.subject time to treatment en_US
dc.subject Time-to-Treatment en_US
dc.subject unspecified side effect en_US
dc.subject very elderly en_US
dc.subject vomiting en_US
dc.title Hydroxychloroquine / azithromycin in COVID-19: The association between time to treatment and case fatality rate en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.tmaid.2021.102163
dc.relation.issn 1873-0442


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