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Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas

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dc.contributor.author Guimarães Alves, A.C.
dc.contributor.author Sukow, N.M.
dc.contributor.author Adelman Cipolla, G.
dc.contributor.author Mendes, M.
dc.contributor.author Leal, T.P.
dc.contributor.author Petzl-Erler, M.L.
dc.contributor.author Lehtonen Rodrigues Souza, R.
dc.contributor.author Rainha de Souza, I.
dc.contributor.author Sanchez, C.
dc.contributor.author Santolalla Robles, Meddly Leslye
dc.contributor.author Loesch, D.
dc.contributor.author Dean, M.
dc.contributor.author Machado, M.
dc.contributor.author Moon, J.-Y.
dc.contributor.author Kaplan, R.
dc.contributor.author North, K.E.
dc.contributor.author Weiss, S.
dc.contributor.author Barreto, M.L.
dc.contributor.author Lima-Costa, M.F.
dc.contributor.author Guio, H.
dc.contributor.author Cáceres, O.
dc.contributor.author Padilla, C.
dc.contributor.author Tarazona-Santos, E.
dc.contributor.author Mata, I.F.
dc.contributor.author Dieguez, E.
dc.contributor.author Raggio, V.
dc.contributor.author Lescano, Andrés
dc.contributor.author Tumas, V.
dc.contributor.author Borges, V.
dc.contributor.author Ferraz, H.B.
dc.contributor.author Rieder, C.R.
dc.contributor.author Schumacher-Schuh, A.
dc.contributor.author Santos-Lobato, B.L.
dc.contributor.author Chana-Cuevas, P.
dc.contributor.author Fernandez, W.
dc.contributor.author Arboleda, G.
dc.contributor.author Arboleda, H.
dc.contributor.author Arboleda-Bustos, C.E.
dc.contributor.author O’Connor, T.D.
dc.contributor.author Beltrame, M.H.
dc.contributor.author Borda, V.
dc.date.accessioned 2021-12-12T20:24:55Z
dc.date.available 2021-12-12T20:24:55Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/10226
dc.description.abstract In adulthood, the ability to digest lactose, the main sugar present in milk of mammals, is a phenotype (lactase persistence) observed in historically herder populations, mainly Northern Europeans, Eastern Africans, and Middle Eastern nomads. As the –13910∗T allele in the MCM6 gene is the most well-characterized allele responsible for the lactase persistence phenotype, the –13910C > T (rs4988235) polymorphism is commonly evaluated in lactase persistence studies. Lactase non-persistent adults may develop symptoms of lactose intolerance when consuming dairy products. In the Americas, there is no evidence of the consumption of these products until the arrival of Europeans. However, several American countries’ dietary guidelines recommend consuming dairy for adequate human nutrition and health promotion. Considering the extensive use of dairy and the complex ancestry of Pan-American admixed populations, we studied the distribution of –13910C > T lactase persistence genotypes and its flanking haplotypes of European origin in 7,428 individuals from several Pan-American admixed populations. We found that the –13910∗T allele frequency in Pan-American admixed populations is directly correlated with allele frequency of the European sources. Moreover, we did not observe any overrepresentation of European haplotypes in the –13910C > T flanking region, suggesting no selective pressure after admixture in the Americas. Finally, considering the dominant effect of the –13910∗T allele, our results indicate that Pan-American admixed populations are likely to have higher frequency of lactose intolerance, suggesting that general dietary guidelines deserve further evaluation across the continent en_US
dc.language.iso eng
dc.publisher Frontiers Media
dc.relation.ispartofseries Frontiers in Genetics
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject –13910C > T en_US
dc.subject African Brazilian en_US
dc.subject ancestry group en_US
dc.subject Article en_US
dc.subject controlled study en_US
dc.subject dairy consumption en_US
dc.subject dairy product en_US
dc.subject DNA extraction en_US
dc.subject European American en_US
dc.subject gene frequency en_US
dc.subject gene linkage disequilibrium en_US
dc.subject genetic variation en_US
dc.subject genome-wide association study en_US
dc.subject genomics en_US
dc.subject genotype en_US
dc.subject geographic distribution en_US
dc.subject haplotype en_US
dc.subject health promotion en_US
dc.subject human en_US
dc.subject lactase en_US
dc.subject lactose intolerance en_US
dc.subject lactose tolerance en_US
dc.subject Latin America en_US
dc.subject major clinical study en_US
dc.subject MCM6 gene en_US
dc.subject minichromosome maintenance protein 6 en_US
dc.subject nutrition en_US
dc.subject nutrition policies en_US
dc.subject phenotype en_US
dc.subject polymerase chain reaction en_US
dc.subject population genetics en_US
dc.subject single nucleotide polymorphism en_US
dc.subject whole genome sequencing en_US
dc.title Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3389/fgene.2021.671079
dc.relation.issn 1664-8021


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