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Fluoroquinolone susceptibility in first-line drug-susceptible M. tuberculosis isolates in Lima, Peru

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dc.contributor.author Schwalb Calderon, Alvaro
dc.contributor.author Cachay Figueroa, Rodrigo Antonio
dc.contributor.author Meza, E.
dc.contributor.author Cáceres Nakiche, Tatiana
dc.contributor.author Blackman, A.
dc.contributor.author Maruri, F.
dc.contributor.author Sterling, T.R.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.date.accessioned 2021-12-12T20:24:56Z
dc.date.available 2021-12-12T20:24:56Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/10247
dc.description.abstract Objective: To determine at two distinct time points the prevalence of resistance to ofloxacin (OFX), the representative class drug of fluoroquinolones (FQs), in M. tuberculosis isolates susceptible to first-line drugs. Results: There were 279 M. tuberculosis isolates from the two cohorts (2004–2005: 238 isolates; 2017: 41 isolates) that underwent OFX drug-susceptibility testing (critical concentration: 2 µg/ml). Of 238 isolates in Cohort 1, no resistance to OFX was detected (95% CI 0–0.016); likewise, in Cohort 2, no resistance to OFX was detected in 41 isolates (95% CI 0–0.086). Our findings suggest that FQ use remains a viable option for the treatment of first-line drug-susceptible TB in Peru en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Research Notes
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Drug resistance en_US
dc.subject Levofloxacin en_US
dc.subject Moxifloxacin en_US
dc.subject Ofloxacin en_US
dc.title Fluoroquinolone susceptibility in first-line drug-susceptible M. tuberculosis isolates in Lima, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s13104-021-05832-0
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 1756-0500


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