DSpace Repository

Validation of a spatial agent-based model for taenia solium transmission (“cystiagent”) against a large prospective trial of control strategies in northern Peru

Show simple item record

dc.contributor.author Pray, I.W.
dc.contributor.author Pizzitutti, F.
dc.contributor.author Bonnet, G.
dc.contributor.author Gonzales-Gustavson, E.
dc.contributor.author Wakeland, W.
dc.contributor.author Pan, W.K.
dc.contributor.author Lambert, W.E.
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author O’neal, S.E.
dc.date.accessioned 2021-12-12T20:24:57Z
dc.date.available 2021-12-12T20:24:57Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/10254
dc.description.abstract Background The pork tapeworm (Taenia solium) is a parasitic helminth that imposes a major health and economic burden on poor rural populations around the world. As recognized by the World Health Organization, a key barrier for achieving control of T. solium is the lack of an accurate and validated simulation model with which to study transmission and evaluate available control and elimination strategies. CystiAgent is a spatially-explicit agent based model for T. solium that is unique among T. solium models in its ability to represent key spatial and environmental features of transmission and simulate spatially targeted interventions, such as ring strategy. Methods/Principal findings We validated CystiAgent against results from the Ring Strategy Trial (RST)–a large cluster-randomized trial conducted in northern Peru that evaluated six unique interventions for T. solium control in 23 villages. For the validation, each intervention strategy was replicated in CystiAgent, and the simulated prevalences of human taeniasis, porcine cysticercosis, and porcine seroincidence were compared against prevalence estimates from the trial. Results showed that CystiAgent produced declines in transmission in response to each of the six intervention strategies, but overestimated the effect of interventions in the majority of vil-lages; simulated prevalences for human taenasis and porcine cysticercosis at the end of the trial were a median of 0.53 and 5.0 percentages points less than prevalence observed at the end of the trial, respectively. Conclusions/Significance The validation of CystiAgent represented an important step towards developing an accurate and reliable T. solium transmission model that can be deployed to fill critical gaps in our understanding of T. solium transmission and control. To improve model accuracy, future versions would benefit from improved data on pig immunity and resistance, field effective-ness of anti-helminthic treatment, and factors driving spatial clustering of T. solium infections including dispersion and contact with T. solium eggs in the environment en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adult en_US
dc.subject Article en_US
dc.subject calibration en_US
dc.subject controlled study en_US
dc.subject enzyme linked immunosorbent assay en_US
dc.subject foraging en_US
dc.subject human en_US
dc.subject neurocysticercosis en_US
dc.subject nonhuman en_US
dc.subject parasite control en_US
dc.subject parasite transmission en_US
dc.subject Peru en_US
dc.subject prospective study en_US
dc.subject randomized controlled trial en_US
dc.subject sensitivity analysis en_US
dc.subject sensitivity and specificity en_US
dc.subject simulation en_US
dc.subject spatiotemporal analysis en_US
dc.subject Taenia solium en_US
dc.subject taeniasis en_US
dc.subject travel en_US
dc.subject validation process en_US
dc.title Validation of a spatial agent-based model for taenia solium transmission (“cystiagent”) against a large prospective trial of control strategies in northern Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0009885
dc.relation.issn 1935-2735


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics