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A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection

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dc.contributor.author Karlsson, L.
dc.contributor.author Das, J.
dc.contributor.author Nilsson, M.
dc.contributor.author Tyrén, A.
dc.contributor.author Pehrson, I.
dc.contributor.author Idh, N.
dc.contributor.author Sayyab, S.
dc.contributor.author Paues, J.
dc.contributor.author Ugarte Gil, Cesar Augusto
dc.contributor.author Méndez-Aranda, M.
dc.contributor.author Lerm, M.
dc.date.accessioned 2021-12-12T20:24:57Z
dc.date.available 2021-12-12T20:24:57Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/10263
dc.description.abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis, spreads via aerosols and the first encounter with the immune system is with the pulmonary-resident immune cells. The role of epigenetic regulations in the immune cells is emerging and we have previously shown that macrophages capacity to kill M. tuberculosis is reflected in the DNA methylome. The aim of this study was to investigate epigenetic modifications in alveolar macrophages and T cells in a cohort of medical students with an increased risk of TB exposure, longitudinally. DNA methylome analysis revealed that a unique DNA methylation profile was present in healthy subjects who later developed latent TB during the study. The profile was reflected in a different overall DNA methylation distribution as well as a distinct set of differentially methylated genes (DMGs). The DMGs were over-represented in pathways related to metabolic reprogramming of macrophages and T cell migration and IFN-γ production, pathways previously reported important in TB control. In conclusion, we identified a unique DNA methylation signature in individuals, with no peripheral immune response to M. tuberculosis antigen who later developed latent TB. Together the study suggests that the DNA methylation status of pulmonary immune cells can reveal who will develop latent TB infection en_US
dc.language.iso eng
dc.publisher Springer Nature
dc.relation.ispartofseries Scientific Reports
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Diseases en_US
dc.subject Immunology en_US
dc.subject Medical research en_US
dc.subject Microbiology en_US
dc.title A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/s41598-021-98542-3
dc.relation.issn 2045-2322


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