Universidad Peruana Cayetano Heredia

Achieving remission or low disease activity is associated with better outcomes in patients with systemic lupus erythematosus: A systematic literature review

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dc.contributor.author Ugarte Gil, Manuel Francisco
dc.contributor.author Mendoza-Pinto, C.
dc.contributor.author Reátegui-Sokolova, C.
dc.contributor.author Pons-Estel, G.J.
dc.contributor.author Van Vollenhoven, R.F.
dc.contributor.author Bertsias, G.
dc.contributor.author Alarcón, Graciela S.
dc.contributor.author Pons-Estel, B.A.
dc.date.accessioned 2021-12-12T20:24:58Z
dc.date.available 2021-12-12T20:24:58Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/10272
dc.description.abstract Background Remission and low disease activity (LDA) have been proposed as the treatment goals for patients with systemic lupus erythematosus (SLE). Several definitions for each have been proposed in the literature. Objective To assess the impact of remission/LDA according to various definitions on relevant outcomes in patients with SLE. Methods This systematic literature review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses using PubMed (1946-week 2, April 2021), Cochrane library (1985-week 2, week 2, April 2021) and EMBASE (1974-week 2, April 2021). We included longitudinal and cross-sectional studies in patients with SLE reporting the impact of remission and LDA (regardless their definition) on mortality, damage accrual, flares, health-related quality of life and other outcomes (cardiovascular risk, hospitalisation and direct costs). The quality of evidence was evaluated using the Newcastle-Ottawa Scale. Results We identified 7497 articles; of them, 31 studies met the inclusion criteria and were evaluated. Some articles reported a positive association with survival, although this was not confirmed in all of them. Organ damage accrual was the most frequently reported outcome, and remission and LDA were reported as protective of this outcome (risk measures varying from 0.04 to 0.95 depending on the definition). Similarly, both states were associated with a lower probability of SLE flares, hospitalisations and a better health-related quality of life, in particular the physical domain. Conclusion Remission and LDA are associated with improvement in multiple outcomes in patients with SLE, thus reinforcing their relevance in clinical practice en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries Lupus Science and Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject health care en_US
dc.subject outcome assessment en_US
dc.subject quality of life en_US
dc.subject systemic lupus erythematosus en_US
dc.title Achieving remission or low disease activity is associated with better outcomes in patients with systemic lupus erythematosus: A systematic literature review en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1136/lupus-2021-000542
dc.relation.issn 2053-8790


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