Universidad Peruana Cayetano Heredia

Increased reliance on carbohydrates for aerobic exercise in highland andean leaf-eared mice, but not in highland lima leaf-eared mice

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dc.contributor.author Schippers, M.-P.
dc.contributor.author Ramirez, O.
dc.contributor.author Arana, M.
dc.contributor.author McClelland, G.B.
dc.date.accessioned 2021-12-12T20:24:58Z
dc.date.available 2021-12-12T20:24:58Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/10285
dc.description.abstract Exercise is an important performance trait in mammals and variation in aerobic capacity and/or substrate allocation during submaximal exercise may be important for survival at high altitude. Comparisons between lowland and highland populations is a fruitful approach to understanding the mechanisms for altitude differences in exercise performance. However, it has only been applied in very few highland species. The leaf-eared mice (LEM, genus Phyllotis) of South America are a promising taxon to uncover the pervasiveness of hypoxia tolerance mechanisms. Here we use lowland and highland populations of Andean and Lima LEM (P. andium and P. limatus), acclimated to common laboratory conditions, to determine exercise-induced maximal oxygen consumption (.VO2 max), and submaximal exercise metabolism. Lowland and highland populations of both species showed no difference in.VO2 max running in either normoxia or hypoxia. When run at 75% of . VO2 max, highland Andean LEM had a greater reliance on carbohydrate oxidation to power exercise. In contrast, highland Lima LEM showed no difference in exercise fuel use compared to their lowland counterparts. The higher carbohydrate oxidation seen in highland Andean LEM was not explained by maximal activities of glycolytic enzymes in the gastrocnemius muscle, which were equivalent to lowlanders. This result is consistent with data on highland deer mouse populations and suggests changes in metabolic regulation may explain altitude differences in exercise performance en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries Metabolites
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject 3 hydroxyacyl coenzyme A dehydrogenase en_US
dc.subject 6 phosphofructokinase en_US
dc.subject aerobic capacity en_US
dc.subject Aerobic capacity en_US
dc.subject aerobic exercise en_US
dc.subject altitude en_US
dc.subject Altitude en_US
dc.subject animal experiment en_US
dc.subject Article en_US
dc.subject body mass en_US
dc.subject carbohydrate en_US
dc.subject carbohydrate metabolism en_US
dc.subject Carbohydrates en_US
dc.subject carbon dioxide en_US
dc.subject citrate synthase en_US
dc.subject controlled study en_US
dc.subject creatine kinase en_US
dc.subject cytochrome c oxidase en_US
dc.subject endurance training en_US
dc.subject enzyme activity en_US
dc.subject exercise en_US
dc.subject exercise intensity en_US
dc.subject Fuel use en_US
dc.subject gastrocnemius muscle en_US
dc.subject glucose en_US
dc.subject glucose transport en_US
dc.subject glycolysis en_US
dc.subject glycolytic enzyme en_US
dc.subject heart rate en_US
dc.subject hexokinase en_US
dc.subject indirect calorimetry en_US
dc.subject isocitrate dehydrogenase en_US
dc.subject lactate dehydrogenase en_US
dc.subject life expectancy en_US
dc.subject lipid oxidation en_US
dc.subject male en_US
dc.subject maximal oxygen uptake en_US
dc.subject metabolic regulation en_US
dc.subject mitochondrial respiration en_US
dc.subject mouse en_US
dc.subject Muscle en_US
dc.subject nonhuman en_US
dc.subject oxygen consumption en_US
dc.subject plant leaf en_US
dc.subject power training en_US
dc.subject pyruvate kinase en_US
dc.subject respirometry en_US
dc.subject Respirometry en_US
dc.subject treadmill exercise en_US
dc.title Increased reliance on carbohydrates for aerobic exercise in highland andean leaf-eared mice, but not in highland lima leaf-eared mice en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/metabo11110750
dc.relation.issn 2218-1989


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