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The international Perinatal Outcomes in the Pandemic (iPOP) study: Protocol

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dc.contributor.author Stock, S.J.
dc.contributor.author Zoega, H.
dc.contributor.author Brockway, M.
dc.contributor.author Mulholland, R.H.
dc.contributor.author Miller, J.E.
dc.contributor.author Been, J.V.
dc.contributor.author Wood, R.
dc.contributor.author Abok, I.I.
dc.contributor.author Alshaikh, B.
dc.contributor.author Ayede, A.I.
dc.contributor.author Bacchini, F.
dc.contributor.author Bhutta, Z.A.
dc.contributor.author Brew, B.K.
dc.contributor.author Brook, J.
dc.contributor.author Calvert, C.
dc.contributor.author Campbell-Yeo, M.
dc.contributor.author Chan, D.
dc.contributor.author Chirombo, J.
dc.contributor.author Connor, K.L.
dc.contributor.author Daly, M.
dc.contributor.author Einarsdóttir, K.
dc.contributor.author Fantasia, I.
dc.contributor.author Franklin, M.
dc.contributor.author Fraser, A.
dc.contributor.author Håberg, S.E.
dc.contributor.author Hui, L.
dc.contributor.author Huicho Oriundo, Luis
dc.contributor.author Magnus, M.C.
dc.contributor.author Morris, A.D.
dc.contributor.author Nagy-Bonnard, L.
dc.contributor.author Nassar, N.
dc.contributor.author Nyadanu, S.D.
dc.contributor.author Iyabode Olabisi, D.
dc.contributor.author Palmer, K.R.
dc.contributor.author Pedersen, L.H.
dc.contributor.author Pereira, G.
dc.contributor.author Racine-Poon, A.
dc.contributor.author Ranger, M.
dc.contributor.author Rihs, T.
dc.contributor.author Saner, C.
dc.contributor.author Sheikh, A.
dc.contributor.author Swift, E.M.
dc.contributor.author Tooke, L.
dc.contributor.author Urquia, M.L.
dc.contributor.author Whitehead, C.
dc.contributor.author Yilgwan, C.
dc.contributor.author Rodriguez, Natalie
dc.contributor.author Burgner, D.
dc.contributor.author Azad, M.B.
dc.contributor.author iPOP Study Team
dc.date.accessioned 2021-12-12T20:24:59Z
dc.date.available 2021-12-12T20:24:59Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/10302
dc.description.abstract Preterm birth is the leading cause of infant death worldwide, but the causes of preterm birth are largely unknown. During the early COVID-19 lockdowns, dramatic reductions in preterm birth were reported; however, these trends may be offset by increases in stillbirth rates. It is important to study these trends globally as the pandemic continues, and to understand the underlying cause(s). Lockdowns have dramatically impacted maternal workload, access to healthcare, hygiene practices, and air pollution - all of which could impact perinatal outcomes and might affect pregnant women differently in different regions of the world. In the international Perinatal Outcomes in the Pandemic (iPOP) Study, we will seize the unique opportunity offered by the COVID-19 pandemic to answer urgent questions about perinatal health. In the first two study phases, we will use population-based aggregate data and standardized outcome definitions to: 1) Determine rates of preterm birth, low birth weight, and stillbirth and describe changes during lockdowns; and assess if these changes are consistent globally, or differ by region and income setting, 2) Determine if the magnitude of changes in adverse perinatal outcomes during lockdown are modified by regional differences in COVID-19 infection rates, lockdown stringency, adherence to lockdown measures, air quality, or other social and economic markers, obtained from publicly available datasets. We will undertake an interrupted time series analysis covering births from January 2015 through July 2020. The iPOP Study will involve at least 121 researchers in 37 countries, including obstetricians, neonatologists, epidemiologists, public health researchers, environmental scientists, and policymakers. We will leverage the most disruptive and widespread 'natural experiment' of our lifetime to make rapid discoveries about preterm birth. Whether the COVID-19 pandemic is worsening or unexpectedly improving perinatal outcomes, our research will provide critical new information to shape prenatal care strategies throughout (and well beyond) the pandemic en_US
dc.language.iso eng
dc.publisher F1000 Research
dc.relation.ispartofseries Wellcome Open Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject COVID-19 en_US
dc.subject Global trends en_US
dc.subject Low birth weight en_US
dc.subject Pandemic lockdowns en_US
dc.subject Perinatal outcomes en_US
dc.subject Preterm birth en_US
dc.subject Stillbirth en_US
dc.title The international Perinatal Outcomes in the Pandemic (iPOP) study: Protocol en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.12688/wellcomeopenres.16507.1
dc.relation.issn 2398-502X


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