DSpace Repository

Andean and Tibetan patterns of adaptation to high altitude

Show simple item record

dc.contributor.author Bigham, Abigail W.
dc.contributor.author Wilson, Megan J.
dc.contributor.author Julian, Colleen G.
dc.contributor.author Kiyamu Tsuchiya, Melisa
dc.contributor.author Vargas, E.
dc.contributor.author León-Velarde, Fabiola
dc.contributor.author Rivera Chira, Maria Concepcion
dc.contributor.author Rodriquez, Carmelo
dc.contributor.author Browne, Vaughn A.
dc.contributor.author Parra, Esteban
dc.contributor.author Brutsaert, Tom D.
dc.contributor.author Moore, Lorna G.
dc.contributor.author Shriver, Mark D.
dc.date.accessioned 2022-01-04T20:29:53Z
dc.date.available 2022-01-04T20:29:53Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10356
dc.description.abstract High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean Altiplano and the Tibetan Plateau for millennia and exhibit unique circulatory, respiratory, and hematological adaptations to life at high altitude. We and others have identified natural selection candidate genes and gene regions for these adaptations using dense genome scan data. One gene previously known to be important in cellular oxygen sensing, egl nine homolog 1 (EGLN1), shows evidence of positive selection in both Tibetans and Andeans. Interestingly, the pattern of variation for this gene differs between the two populations. Continued research among Tibetan populations has identified statistical associations between hemoglobin concentration and single nucleotide polymorphism (SNP) genotype at EGLN1 and a second gene, endothelial PAS domain protein 1 (EPAS1). en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries American Journal of Human Biology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject genetics en_US
dc.subject metabolism en_US
dc.subject single nucleotide polymorphism en_US
dc.subject South America en_US
dc.subject human en_US
dc.subject hemoglobin en_US
dc.subject Hemoglobins en_US
dc.subject altitude en_US
dc.subject acclimatization en_US
dc.subject American Indian en_US
dc.subject Indians en_US
dc.subject Polymorphism, Single Nucleotide en_US
dc.subject Asian en_US
dc.subject adaptation en_US
dc.subject gene expression regulation en_US
dc.subject Physiological en_US
dc.subject China en_US
dc.subject Asian Continental Ancestry Group en_US
dc.subject Tibet en_US
dc.title Andean and Tibetan patterns of adaptation to high altitude en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/ajhb.22358
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.00
dc.relation.issn 1520-6300


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics