Universidad Peruana Cayetano Heredia
Andean and Tibetan patterns of adaptation to high altitude
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| dc.contributor.author | Bigham, Abigail W. | |
| dc.contributor.author | Wilson, Megan J. | |
| dc.contributor.author | Julian, Colleen G. | |
| dc.contributor.author | Kiyamu Tsuchiya, Melisa | |
| dc.contributor.author | Vargas, E. | |
| dc.contributor.author | León-Velarde, Fabiola | |
| dc.contributor.author | Rivera Chira, Maria Concepcion | |
| dc.contributor.author | Rodriquez, Carmelo | |
| dc.contributor.author | Browne, Vaughn A. | |
| dc.contributor.author | Parra, Esteban | |
| dc.contributor.author | Brutsaert, Tom D. | |
| dc.contributor.author | Moore, Lorna G. | |
| dc.contributor.author | Shriver, Mark D. | |
| dc.date.accessioned | 2022-01-04T20:29:53Z | |
| dc.date.available | 2022-01-04T20:29:53Z | |
| dc.date.issued | 2013 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/10356 | |
| dc.description.abstract | High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean Altiplano and the Tibetan Plateau for millennia and exhibit unique circulatory, respiratory, and hematological adaptations to life at high altitude. We and others have identified natural selection candidate genes and gene regions for these adaptations using dense genome scan data. One gene previously known to be important in cellular oxygen sensing, egl nine homolog 1 (EGLN1), shows evidence of positive selection in both Tibetans and Andeans. Interestingly, the pattern of variation for this gene differs between the two populations. Continued research among Tibetan populations has identified statistical associations between hemoglobin concentration and single nucleotide polymorphism (SNP) genotype at EGLN1 and a second gene, endothelial PAS domain protein 1 (EPAS1). | en_US |
| dc.language.iso | eng | |
| dc.publisher | Wiley | |
| dc.relation.ispartofseries | American Journal of Human Biology | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | genetics | en_US |
| dc.subject | metabolism | en_US |
| dc.subject | single nucleotide polymorphism | en_US |
| dc.subject | South America | en_US |
| dc.subject | human | en_US |
| dc.subject | hemoglobin | en_US |
| dc.subject | Hemoglobins | en_US |
| dc.subject | altitude | en_US |
| dc.subject | acclimatization | en_US |
| dc.subject | American Indian | en_US |
| dc.subject | Indians | en_US |
| dc.subject | Polymorphism, Single Nucleotide | en_US |
| dc.subject | Asian | en_US |
| dc.subject | adaptation | en_US |
| dc.subject | gene expression regulation | en_US |
| dc.subject | Physiological | en_US |
| dc.subject | China | en_US |
| dc.subject | Asian Continental Ancestry Group | en_US |
| dc.subject | Tibet | en_US |
| dc.title | Andean and Tibetan patterns of adaptation to high altitude | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1002/ajhb.22358 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#1.06.00 | |
| dc.relation.issn | 1520-6300 |
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