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Erythrocytosis: The HIF pathway in control

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dc.contributor.author Franke, Kristin
dc.contributor.author Gassmann, Max
dc.contributor.author Wielockx, Ben
dc.date.accessioned 2022-01-04T20:29:54Z
dc.date.available 2022-01-04T20:29:54Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10392
dc.description.abstract Organisms living under aerobic conditions need oxygen for the metabolic conversion of nutrition into energy. With the appearance of increasingly complex animals, a specialized transport system (erythrocytes) arose during evolution to provide oxygen to virtually every single cell in the body. Moreover, in case of low environmental partial pressure of oxygen, the number of erythrocytes automatically increases to preserve sustained oxygen delivery. This process relies predominantly on the cytokine erythropoietin (Epo) and its transcription factor hypoxia inducible factor (HIF), whereas the von Hippel-Lindau (VHL) ubiquitin ligase as well as the oxygen-sensitive prolyl hydroxylases (PHDs) represent essential regulators of this oxygen-sensing system. Deregulation of particular members of this pathway (eg, PHD2, HIF2α, VHL) lead to disorders in blood homeostasis as a Results: of insufficient (anemia) or excessive (erythrocytosis) red blood cell production. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Blood
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Erythrocytosis en_US
dc.subject oxygen en_US
dc.subject hypoxia en_US
dc.subject anemia en_US
dc.subject transcription factor en_US
dc.title Erythrocytosis: The HIF pathway in control en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1182/blood-2013-01-478065
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.06
dc.relation.issn 1528-0020


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