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Characterizing the syphilis epidemic among men who have sex with men in Lima, Peru to identify new treatment and control strategies

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dc.contributor.author Deiss, Robert G.
dc.contributor.author León Sandoval, Segundo Ramos
dc.contributor.author Konda, KelikaA.
dc.contributor.author Brown, Brandon
dc.contributor.author Segura, Eddy R.
dc.contributor.author Galea, Jerome T.
dc.contributor.author Caceres Palacios, Carlos Fernando
dc.contributor.author Klausner, Jeffrey D.
dc.date.accessioned 2022-01-04T20:29:55Z
dc.date.available 2022-01-04T20:29:55Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10396
dc.description.abstract Background: Syphilis is an important sexually transmitted infection (STI) with serious public health consequences. Among men who have sex with men (MSM) in Lima, the prevalence and incidence are extraordinarily high. Current syndromic approaches, however, fail to identify asymptomatic cases, and in settings where large proportions of individuals test positive again after treatment, it is frequently difficult to distinguish treatment failure from re-infection. Thus, new approaches are needed to improve treatment strategies and public health control efforts. Methods/Design: Study participants will undergo baseline testing for syphilis infection along with a behavioral survey covering demographics, sexual behavior, drug and alcohol abuse and health-care seeking behavior. The cohort will be followed for 18 months at three-month intervals. Blood and earlobe scrapings will also be collected for T. pallidum DNA testing, to create molecular markers for subtyping. We will also perform cytokine testing on collected samples in order to create host immunologic profiles associated with recurrence, re-infection, treatment failure and success. Discussion: Advances in social epidemiology, molecular typing and characterization of host immune responses will offer promise in developing new understandings of syphilis management. We will share our findings with the Peruvian Ministry of Health and other public health organizations, to identify new approaches of case detection and successful treatment. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject HIV en_US
dc.subject human en_US
dc.subject major clinical study en_US
dc.subject single drug dose en_US
dc.subject disease surveillance en_US
dc.subject disease association en_US
dc.subject sexual behavior en_US
dc.subject Homosexuality, Male en_US
dc.subject demography en_US
dc.subject cohort analysis en_US
dc.subject Cohort Studies en_US
dc.subject article en_US
dc.subject doxycycline en_US
dc.subject syphilis en_US
dc.subject epidemic en_US
dc.subject alcohol abuse en_US
dc.subject gamma interferon en_US
dc.subject interleukin 10 en_US
dc.subject tumor necrosis factor alpha en_US
dc.subject treatment duration en_US
dc.subject treatment planning en_US
dc.subject immune response en_US
dc.subject Molecular epidemiology en_US
dc.subject dose response en_US
dc.subject men who have sex with men en_US
dc.subject help seeking behavior en_US
dc.subject antibiotic resistance en_US
dc.subject control strategy en_US
dc.subject drug abuse en_US
dc.subject Treponema pallidum en_US
dc.subject molecular typing en_US
dc.subject penicillin G en_US
dc.subject Cytokine en_US
dc.subject Epidemics en_US
dc.subject host resistance en_US
dc.subject interleukin 2 en_US
dc.subject Macrolide resistance en_US
dc.subject Men who have sex with men (MSM) en_US
dc.subject neurosyphilis en_US
dc.subject primary infection en_US
dc.subject probenecid en_US
dc.subject procaine penicillin en_US
dc.subject reinfection en_US
dc.subject secondary syphilis en_US
dc.subject T. pallidum en_US
dc.title Characterizing the syphilis epidemic among men who have sex with men in Lima, Peru to identify new treatment and control strategies en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/1471-2334-13-426
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1471-2334


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