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Genetic variability of Mycobacterium tuberculosis complex in patients with no known risk factors for MDR-TB in the North-eastern part of Lima, Peru

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dc.contributor.author Barletta, Francesca
dc.contributor.author Otero Vegas, Larissa
dc.contributor.author Collantes, Jimena
dc.contributor.author Asto, Belisa
dc.contributor.author de Jong, Bouke C.
dc.contributor.author Seas Ramos, Carlos Rafael
dc.contributor.author Rigouts, Leen
dc.date.accessioned 2022-01-04T20:29:55Z
dc.date.available 2022-01-04T20:29:55Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10397
dc.description.abstract Background: The aim of this study was to investigate the genetic diversity among Mycobacterium tuberculosis complex circulating in patients with no known risk factors for multi-drug resistant (MDR) tuberculosis (TB) living in a high MDR burden area and analyze the relationship between genotypes, primary drug resistance and age. Methods: Samples were collected during January-July 2009. Isolates were tested for drug susceptibility to first-line drugs and were genotyped by spoligotyping and the 15-loci Mycobacterial Interspersed Repetitive Unit (MIRU15). Results: Among the 199 isolates analyzed, 169 (84.9%) were identified in the SpolDB4.0 and 30 (15.1%) could not be matched to any lineage. The most prevalent lineage was Haarlem (29.6%), followed by T (15.6%), Beijing (14.1%), Latin American Mediterranean (12.6%) and U (8.5%). A few isolates belonged to the X and S clades (4.5%). Spoligotype analysis identified clustering among 148 of 169 isolates, whereas with MIRU15 all isolates were unique. Out of 197 strains; 31.5% were resistant to at least one drug, 7.5% were MDR and 22.3% showed any resistance to isoniazid. Conclusion: In contrast with other Latin-American countries where LAM lineage is the most predominant, we found the spoligotype 50 from the Haarlem lineage as the most common. None of the prevailing lineages showed a significant association with age or resistance to isoniazid and/or rifampicin. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Middle Aged en_US
dc.subject Peru en_US
dc.subject Prospective Studies en_US
dc.subject Microbial Sensitivity Tests en_US
dc.subject Genotype en_US
dc.subject Genetic Variation en_US
dc.subject Antitubercular en_US
dc.subject Mycobacterium tuberculosiseffects en_US
dc.subject Tuberculosis en_US
dc.title Genetic variability of Mycobacterium tuberculosis complex in patients with no known risk factors for MDR-TB in the North-eastern part of Lima, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/1471-2334-13-397
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1471-2334


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