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dc.contributor.author | Barletta, Francesca | |
dc.contributor.author | Otero Vegas, Larissa | |
dc.contributor.author | Collantes, Jimena | |
dc.contributor.author | Asto, Belisa | |
dc.contributor.author | de Jong, Bouke C. | |
dc.contributor.author | Seas Ramos, Carlos Rafael | |
dc.contributor.author | Rigouts, Leen | |
dc.date.accessioned | 2022-01-04T20:29:55Z | |
dc.date.available | 2022-01-04T20:29:55Z | |
dc.date.issued | 2013 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/10397 | |
dc.description.abstract | Background: The aim of this study was to investigate the genetic diversity among Mycobacterium tuberculosis complex circulating in patients with no known risk factors for multi-drug resistant (MDR) tuberculosis (TB) living in a high MDR burden area and analyze the relationship between genotypes, primary drug resistance and age. Methods: Samples were collected during January-July 2009. Isolates were tested for drug susceptibility to first-line drugs and were genotyped by spoligotyping and the 15-loci Mycobacterial Interspersed Repetitive Unit (MIRU15). Results: Among the 199 isolates analyzed, 169 (84.9%) were identified in the SpolDB4.0 and 30 (15.1%) could not be matched to any lineage. The most prevalent lineage was Haarlem (29.6%), followed by T (15.6%), Beijing (14.1%), Latin American Mediterranean (12.6%) and U (8.5%). A few isolates belonged to the X and S clades (4.5%). Spoligotype analysis identified clustering among 148 of 169 isolates, whereas with MIRU15 all isolates were unique. Out of 197 strains; 31.5% were resistant to at least one drug, 7.5% were MDR and 22.3% showed any resistance to isoniazid. Conclusion: In contrast with other Latin-American countries where LAM lineage is the most predominant, we found the spoligotype 50 from the Haarlem lineage as the most common. None of the prevailing lineages showed a significant association with age or resistance to isoniazid and/or rifampicin. | en_US |
dc.language.iso | eng | |
dc.publisher | BioMed Central | |
dc.relation.ispartofseries | BMC Infectious Diseases | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Humans | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Peru | en_US |
dc.subject | Prospective Studies | en_US |
dc.subject | Microbial Sensitivity Tests | en_US |
dc.subject | Genotype | en_US |
dc.subject | Genetic Variation | en_US |
dc.subject | Antitubercular | en_US |
dc.subject | Mycobacterium tuberculosiseffects | en_US |
dc.subject | Tuberculosis | en_US |
dc.title | Genetic variability of Mycobacterium tuberculosis complex in patients with no known risk factors for MDR-TB in the North-eastern part of Lima, Peru | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1186/1471-2334-13-397 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.08 | |
dc.relation.issn | 1471-2334 |
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