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Extended spectrum β-lactamase producers among nosocomial Enterobacteriaceae in Latin America

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dc.contributor.author Guzmán-Blanco, Manuel
dc.contributor.author Labarca, Jaime A.
dc.contributor.author Villegas, Maria Virginia
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.date.accessioned 2022-01-04T20:29:55Z
dc.date.available 2022-01-04T20:29:55Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/10404
dc.description.abstract To review the epidemiology of nosocomial extended spectrum -lactamase-producing Enterobacteriaceae in Latin America, a systematic search ofthe biomedical literature (PubMed) was performed for articles published since 2005. Rates of nosocomial infections caused by extended spectrum -lactamase-producing Enterobacteriaceae in Latin America have increased since 2005. Up to 32% of Escherichia coli and up to 58% of Klebsiella pneumoniae isolates are extended spectrum -lactamase-positive, rates that are higher than in other world regions. From a region-wide perspective, 11–25% of E. coli isolates and 45–53% of K. pneumoniae isolates were nonsusceptible to third-generation cephalosporins. At the country level, there was a wide range in Enterobacteriaceae resistance rates to third-generation cephalosporins, with especially high rates of resistance to E. coli in Guatemala, Honduras, and Mexico, and high resistance rates to Klebsiella spp. in Argentina, Brazil, Chile, Guatemala, Honduras, and Paraguay. Susceptibility of extended spectrum -lactamase-producing Enterobacteriaceae to cefepime, fluoroquinolones, ampicillin/sulbactam, aminoglycosides, and piperacillin/tazobactam has also been compromised, leaving the carbapenems, tigecycline, and colistin as the only antibiotics with >90% susceptibility rates. There is a steady increase in the prevalence and types of extended spectrum -lactamases produced by Enterobacteriaceae isolates in Latin American hospitals (particularly CTX-Ms), suggesting endemic conditions overlaid by clonal outbreaks. Appropriate treatment decisions and infection control strategies informed by surveillance of regional and local susceptibilities and mechanisms of resistance are required to mitigate this major public health concern. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Brazilian Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Escherichia coli en_US
dc.subject Klebsiella en_US
dc.subject Latin America en_US
dc.subject Bacterial resistance en_US
dc.title Extended spectrum β-lactamase producers among nosocomial Enterobacteriaceae in Latin America en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.bjid.2013.10.005
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1678-4391


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