Universidad Peruana Cayetano Heredia

Intestinal protozoan infections in the immunocompromised host

Mostrar el registro sencillo del ítem

dc.contributor.author Marcos, Luis A.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.date.accessioned 2022-01-04T20:29:56Z
dc.date.available 2022-01-04T20:29:56Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10426
dc.description.abstract Purpose of review: Intestinal protozoa are becoming increasingly recognized as significant pathogens in immunocompromised hosts. However, pathogenesis of infection is still poorly understood, diagnostic tests remain insensitive, and management continues to pose a challenge. Recent findings: Invasion by intestinal protozoa can be facilitated by impaired host T-cell immune response, although the exact pathogenesis at the cellular level is unclear. HIV-infected and transplant patients have been reported to have the highest risk for developing severe disease. Cryptosporidium is the most common parasite encountered in the immunocompromised host, followed by Cyclospora and Isospora. In recent years, Microsporidia and Blastocystis have also emerged as important players, due in part to improved molecular diagnostic assays. Effective drugs against these parasites in immunocompromised patients have not been reported in recent years. When possible, reducing the level of immunosuppression seems to be the most effective treatment strategy in combination with adjunctive antiparasitic therapy. Summary: Despite that intestinal protozoan infections cause greater morbidity and mortality in the immunocompromised host, their pathogenesis in the setting of immunosuppression is poorly understood and efforts to develop new therapeutic agents are rather limited. Improving detection and identification of species or subtypes by PCR will Results: in improved management decisions and a better understanding of the epidemiology of intestinal protozoa. Favorable clinical outcomes can be achieved by early detection and effective treatment of the infection. Further research on key aspects of pathogenesis at the cellular level in humans is needed. en_US
dc.language.iso eng
dc.publisher Wolters Kluwer Health
dc.relation.ispartofseries Current Opinion in Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject HIV en_US
dc.subject unclassified drug en_US
dc.subject human en_US
dc.subject Peru en_US
dc.subject adaptive immunity en_US
dc.subject albendazole en_US
dc.subject innate immunity en_US
dc.subject parasite prevalence en_US
dc.subject Risk Factors en_US
dc.subject Human immunodeficiency virus infection en_US
dc.subject Ethiopia en_US
dc.subject India en_US
dc.subject infection rate en_US
dc.subject multiplex polymerase chain reaction en_US
dc.subject immunocompromised patient en_US
dc.subject Immunocompromised Host en_US
dc.subject infection risk en_US
dc.subject Brazil en_US
dc.subject review en_US
dc.subject humoral immunity en_US
dc.subject pathogenesis en_US
dc.subject antimicrobial therapy en_US
dc.subject high risk patient en_US
dc.subject cotrimoxazole en_US
dc.subject protozoal protein en_US
dc.subject intestine parasite en_US
dc.subject Thailand en_US
dc.subject metronidazole en_US
dc.subject itraconazole en_US
dc.subject paromomycin en_US
dc.subject Cyclospora cayetanensis en_US
dc.subject cyclosporiasis en_US
dc.subject Isospora belli en_US
dc.subject blastocystosis en_US
dc.subject cp20 protein en_US
dc.subject cryptosporidiosis en_US
dc.subject Cryptosporidium hominis en_US
dc.subject Cryptosporidium parvum en_US
dc.subject eye infection en_US
dc.subject fumagillin en_US
dc.subject furazolidone en_US
dc.subject immune evasion en_US
dc.subject immunocompromised en_US
dc.subject infectious diarrhea en_US
dc.subject Intestinal Diseases, Parasitic en_US
dc.subject intestinal parasites en_US
dc.subject isosporiasis en_US
dc.subject Malaysia en_US
dc.subject microsporidiosis en_US
dc.subject nitazoxanide en_US
dc.subject protozoa en_US
dc.subject protozoal infection en_US
dc.subject Protozoan Infections en_US
dc.subject ribosome RNA en_US
dc.subject sclerosing cholangitis en_US
dc.subject tinidazole en_US
dc.subject transplant en_US
dc.title Intestinal protozoan infections in the immunocompromised host en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1097/QCO.0b013e3283630be3
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1473-6527


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas