Universidad Peruana Cayetano Heredia

Concentrations of urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in women exposed to woodsmoke in a cookstove intervention study in San Marcos, Peru

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dc.contributor.author Commodore, Adwao A.
dc.contributor.author Zhang, Junfeng Jim
dc.contributor.author Chang, Yan
dc.contributor.author Hartinger Peña, Stella Maria
dc.contributor.author Lanata, Claudio F.
dc.contributor.author Mäusezahl, Daniel
dc.contributor.author Gil, Ana I.
dc.contributor.author Hall, Daniel B.
dc.contributor.author Aguilar-Villalobos, Manuel
dc.contributor.author Vena, John E.
dc.contributor.author Wang, Jia-Sheng
dc.contributor.author Naeher, Luke P.
dc.date.accessioned 2022-01-04T20:29:57Z
dc.date.available 2022-01-04T20:29:57Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10443
dc.description.abstract Nearly half of the world's population is exposed to household air pollution (HAP) due to long hours spent in close proximity to unvented cooking fires. The effect of woodsmoke exposure on oxidative stress was examined by investigating the association between woodsmoke exposure and biomarkers of DNA oxidation (8-hydroxy-2′-deoxyguanosine [8-OHdG]) and lipid peroxidation (8-isoprostane) among control and intervention stove users. HAP exposure assessment was conducted within the framework of a community-randomized controlled trial of 51 communities in San Marcos Province, Cajamarca Region, Peru. The first morning urine voids after 48 h HAP exposure assessment from a subset of 45 control and 39 intervention stove users were analyzed for 8-OHdG and 8-isoprostane. General linear models and correlation analyses were performed. Urinary oxidative stress biomarkers ranged from 11.2 to 2270.0 μg/g creatinine (median: 132.6 μg/g creatinine) for 8-OHdG and from 0.1 to 4.5 μg/g creatinine (median: 0.8 μg/g creatinine) for 8-isoprostane among all study subjects (n = 84). After controlling for the effects of traffic in the community and eating food exposed to fire among all subjects, cooking time was weakly, but positively associated with urinary 8-OHdG (r = 0.29, p = 0.01, n = 80). Subjects' real-time personal CO exposures were negatively associated with 8-OHdG, particularly the maximum 30-second CO exposure during the sampling period (r = − 0.32, p = 0.001, n = 73). 48 h time integrated personal PM2.5 was negatively, but marginally associated with urinary 8-isoprostane (r = − 0.21, p = 0.09, n = 69) after controlling for the effect of distance of homes to the road. Urinary 8-isoprostane levels reported in the available literature are comparable to results found in the current study. However there were relatively high levels of urinary 8-OHdG compared to data in the available literature for 8-OHdG excretion. Results suggest a sustained systemic oxidative stress among these Peruvian women chronically exposed to wood smoke. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Environment International
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject 8-OHdG en_US
dc.subject 8-Isoprostane en_US
dc.subject Cookstove en_US
dc.subject Household air pollution en_US
dc.subject Oxidative stress en_US
dc.subject Peru en_US
dc.title Concentrations of urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in women exposed to woodsmoke in a cookstove intervention study in San Marcos, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.envint.2013.08.013
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 1873-6750


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