Universidad Peruana Cayetano Heredia

Effect of urbanisation on the relationship between total serum IgE and asthma

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dc.contributor.author Checkley, William
dc.contributor.author Robinson, Colin L.
dc.contributor.author Baumann, Lauren M.
dc.contributor.author Romero Rivero, Karina Maribel
dc.contributor.author Combe, Juan M.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Wise, Robert A.
dc.contributor.author Hamilton, Robert G.
dc.contributor.author Gonzalvez, Guillermo
dc.contributor.author Cama, Vitaliano
dc.contributor.author Hansel, Nadia N.
dc.date.accessioned 2022-01-04T20:29:57Z
dc.date.available 2022-01-04T20:29:57Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10454
dc.description.abstract It is unclear if the relationship of total serum IgE with asthma varies with degree of urbanisation. We hypothesised that the relationship of total serum IgE to asthma is more pronounced in an urban versus a rural environment. We enrolled 1441 children aged 13–15 years in a peri-urban shanty town in Lima, Peru (n=725) and 23 villages in rural Tumbes, Peru (n=716). We asked participants about asthma and allergy symptoms, environmental exposures and sociodemographics; and performed spirometry, and exhaled nitric oxide and allergy skin testing. We obtained blood for total serum IgE in 1143 (79%) participants. Geometric means for total serum IgE were higher in Lima versus Tumbes (262 versus 192 kU·L−1; p<0.001). The odds of asthma increased by factors of 1.6 (95% CI 1.3–2.0) versus 1.4 (95% CI 0.9–2.1) per log unit increase in total serum IgE in Lima versus Tumbes, respectively. Atopy was an effect modifier of the relationship of total serum IgE on asthma. Among atopics and non-atopics, the odds of asthma increased by a factor of 2.0 (95% CI 1.5–2.7) and 1.0 (95% CI 0.7–1.4) per log unit increase in total serum IgE, respectively. Total serum IgE was associated with atopic asthma but not with non-atopic asthma. Urbanisation did not appear to be an effect modifier of this relationship. en_US
dc.language.iso eng
dc.publisher European Respiratory Society
dc.relation.ispartofseries European Respiratory Journal
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Cross-Sectional Studies en_US
dc.subject Humans en_US
dc.subject major clinical study en_US
dc.subject Peru en_US
dc.subject prevalence en_US
dc.subject controlled study en_US
dc.subject immunoglobulin E en_US
dc.subject priority journal en_US
dc.subject Risk Factors en_US
dc.subject urban area en_US
dc.subject disease association en_US
dc.subject sex difference en_US
dc.subject comparative study en_US
dc.subject body mass en_US
dc.subject obesity en_US
dc.subject demography en_US
dc.subject forced vital capacity en_US
dc.subject spirometry en_US
dc.subject environmental exposure en_US
dc.subject Environmental Exposure en_US
dc.subject Inflammation en_US
dc.subject Odds Ratio en_US
dc.subject article en_US
dc.subject urbanization en_US
dc.subject Urbanization en_US
dc.subject forced expiratory volume en_US
dc.subject nitric oxide en_US
dc.subject rural area en_US
dc.subject asthma en_US
dc.subject Social Class en_US
dc.subject Nitric Oxide en_US
dc.subject Asthma en_US
dc.subject Hypersensitivity en_US
dc.subject immunoglobulin blood level en_US
dc.subject skin test en_US
dc.subject airway obstruction en_US
dc.subject allergic asthma en_US
dc.subject Asthma clinical/basic investigations en_US
dc.subject atopic asthma en_US
dc.subject Atopic asthma en_US
dc.subject epidemiology of asthma en_US
dc.subject Epidemiology of asthma en_US
dc.subject Immunoglobulin E en_US
dc.subject respiratory tract inflammation en_US
dc.subject Skin Tests en_US
dc.title Effect of urbanisation on the relationship between total serum IgE and asthma en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1183/09031936.00025512
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1399-3003


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