Universidad Peruana Cayetano Heredia

Treatment failure in leishmaniasis: Drug-resistance or another (epi-) phenotype?

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dc.contributor.author Vanaerschot, Manu
dc.contributor.author Dumetz, Franck
dc.contributor.author Roy, Syamal
dc.contributor.author Ponte-Sucre, Alicia
dc.contributor.author Arévalo Zelada, Jorge Luis
dc.contributor.author Dujardin, Jean-Claude
dc.date.accessioned 2022-01-04T20:29:58Z
dc.date.available 2022-01-04T20:29:58Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/10462
dc.description.abstract Two major leishmaniasis treatments have shown a significant decrease in effectiveness in the last few decades, mostly in the Indian subcontinent but also in other endemic areas. Drug resistance of Leishmania correlated only partially to treatment failure (TF) of pentavalent antimonials, and has so far proved not to be important for the increased miltefosine relapse rates observed in the Indian subcontinent. While other patient- or drug-related factors could also have played a role, recent studies identified several parasite features such as infectivity and host manipulation skills that might contribute to TF. This perspective aims to discuss how different parasitic features other than drug resistance can contribute to TF of leishmaniasis and how this may vary between different epidemiological contexts. en_US
dc.language.iso eng
dc.publisher Taylor and Francis
dc.relation.ispartofseries Expert Review of Anti-Infective Therapy
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Drug resistance en_US
dc.subject leishmania en_US
dc.subject miltefosine en_US
dc.subject pentavalent antimonials en_US
dc.subject treatment failure en_US
dc.title Treatment failure in leishmaniasis: Drug-resistance or another (epi-) phenotype? en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1586/14787210.2014.916614
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.07
dc.relation.issn 1744-8336


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