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Genomic Correlates of Atherosclerosis in Ancient Humans

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dc.contributor.author Zink, Albert
dc.contributor.author Wann, L. Samuel
dc.contributor.author Thompson, Randall C.
dc.contributor.author Keller, Andreas
dc.contributor.author Maixner, Frank
dc.contributor.author Allam, Adel H.
dc.contributor.author Finch, Caleb E.
dc.contributor.author Frohlich, Bruno
dc.contributor.author Kaplan, Hillard
dc.contributor.author Lombardi, Guido P.
dc.contributor.author Sutherland, M. Linda
dc.contributor.author Sutherland, James D.
dc.contributor.author Watson, Lucia
dc.contributor.author Cox, Samantha L.
dc.contributor.author Miyamoto, Michael I.
dc.contributor.author Narula, Jagat
dc.contributor.author Stewart, Alexandre F. R.
dc.contributor.author Thomas, Gregory S.
dc.contributor.author Krause, Johannes
dc.date.accessioned 2022-01-04T20:29:58Z
dc.date.available 2022-01-04T20:29:58Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/10478
dc.description.abstract Paleogenetics offers a unique opportunity to study human evolution, population dynamics, and disease evolution in situ. Although histologic and computed x-ray tomographic investigations of ancient mummies have clearly shown that atherosclerosis has been present in humans for more than 5,000 years, limited data are available on the presence of genetic predisposition for cardiovascular disease in ancient human populations. In a previous whole-genome study of the Tyrolean Iceman, a 5,300-year-old glacier mummy from the Alps, an increased risk for coronary heart disease was detected. The Iceman's genome revealed several single nucleotide polymorphisms that are linked with cardiovascular disease in genome-wide association studies. Future genetic studies of ancient humans from various geographic origins and time periods have the potential to provide more insights into the presence and possible changes of genetic risk factors in our ancestors. The study of ancient humans and a better understanding of the interaction between environmental and genetic influences on the development of heart diseases may lead to a more effective prevention and treatment of the most common cause of death in the modern world. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Global Heart
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject genetics en_US
dc.subject single nucleotide polymorphism en_US
dc.subject human en_US
dc.subject priority journal en_US
dc.subject cardiovascular disease en_US
dc.subject radiography en_US
dc.subject cause of death en_US
dc.subject review en_US
dc.subject gene frequency en_US
dc.subject genetic association en_US
dc.subject environmental factor en_US
dc.subject Genomics en_US
dc.subject cardiovascular risk en_US
dc.subject Italy en_US
dc.subject DNA en_US
dc.subject computer assisted tomography en_US
dc.subject Tomography, X-Ray Computed en_US
dc.subject atherosclerosis en_US
dc.subject Atherosclerosis en_US
dc.subject Egypt en_US
dc.subject Mummies en_US
dc.subject paleopathology en_US
dc.subject genetic predisposition en_US
dc.subject genetic risk en_US
dc.subject genome en_US
dc.subject genomics en_US
dc.subject geographic origin en_US
dc.subject glacier en_US
dc.subject heart disease en_US
dc.subject Imaging, Three-Dimensional en_US
dc.subject ischemic heart disease en_US
dc.subject physical anthropology en_US
dc.subject three dimensional imaging en_US
dc.subject X ray en_US
dc.title Genomic Correlates of Atherosclerosis in Ancient Humans en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.gheart.2014.03.2453
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.04
dc.relation.issn 2211-8179 


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