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Chronic exposure to biomass fuel is associated with increased carotid artery intima-media thickness and a higher prevalence of atherosclerotic plaque

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dc.contributor.author Painschab, Matthew S.
dc.contributor.author Davila-Roman, Victor G.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Vasquez-Villar, Angel D.
dc.contributor.author Pollard, Suzanne L.
dc.contributor.author Wise, Robert A.
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Checkley, William
dc.date.accessioned 2022-01-04T20:29:59Z
dc.date.available 2022-01-04T20:29:59Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10490
dc.description.abstract Background Biomass fuels are used for cooking in the majority of rural households worldwide. While their use is associated with an increased risk of lung diseases and all-cause mortality, the effects on cardiovascular disease (CVD) are not well characterised. Exposure to biomass fuel smoke has been associated with lung-mediated inflammation and oxidative stress, which may increase the risk of atherosclerosis as evaluated by carotid intima-media thickness (CIMT), carotid atherosclerotic plaque prevalence and blood pressure. Methods: A cross-sectional study was performed in 266 adults aged ≥35 years in Puno, Peru (3825 m above sea level). We stratified participants by their long-term history of exposure to clean fuel (n=112) or biomass fuel (n=154) and measured 24 h indoor particulate matter (PM2.5) in a random subset (n=84). Participants completed questionnaires and underwent a clinical assessment, laboratory analyses and carotid artery ultrasound. The main outcome measures were CIMT, carotid plaque and blood pressure. Results The groups were similar in age and gender. The biomass fuel group had greater unadjusted mean CIMT (0.66 vs 0.60 mm; p<0.001), carotid plaque prevalence (26% vs 14%; p=0.03), systolic blood pressure (118 vs 111 mm Hg; p<0.001) and median household PM2.5 (280 vs 14 µg/m3; p<0.001). In multivariable regression, the biomass fuel group had greater mean CIMT (mean difference=0.03 mm, 95% CI 0.01 to 0.06; p=0.02), a higher prevalence of carotid plaques (OR=2.6, 95% CI 1.1 to 6.0; p=0.03) and higher systolic blood pressure (mean difference=9.2 mm Hg, 95% CI 5.4 to 13.0; p<0.001). Conclusions Chronic exposure to biomass fuel was associated with increased CIMT, increased prevalence of atherosclerotic plaques and higher blood pressure. These findings identify biomass fuel use as a risk factor for CVD, which may have important global health implications. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries Heart
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Unclassified drug en_US
dc.subject cross-sectional study en_US
dc.subject human en_US
dc.subject major clinical study en_US
dc.subject Middle Aged en_US
dc.subject Peru en_US
dc.subject prevalence en_US
dc.subject questionnaire en_US
dc.subject controlled study en_US
dc.subject Prevalence en_US
dc.subject priority journal en_US
dc.subject Cardiovascular Diseases en_US
dc.subject disease association en_US
dc.subject age en_US
dc.subject Time Factors en_US
dc.subject Urban Population en_US
dc.subject cohort analysis en_US
dc.subject clinical assessment en_US
dc.subject biomass en_US
dc.subject blood pressure en_US
dc.subject echography en_US
dc.subject fuel en_US
dc.subject long term exposure en_US
dc.subject systolic blood pressure en_US
dc.subject Cooking en_US
dc.subject article en_US
dc.subject Follow-Up Studies en_US
dc.subject particulate matter en_US
dc.subject gender en_US
dc.subject arterial wall thickness en_US
dc.subject biomass fuel en_US
dc.subject carotid atherosclerosis en_US
dc.subject Carotid Intima-Media Thickness en_US
dc.subject Disease Progression en_US
dc.subject laboratory test en_US
dc.subject Oils en_US
dc.subject Plaque, Atherosclerotic en_US
dc.title Chronic exposure to biomass fuel is associated with increased carotid artery intima-media thickness and a higher prevalence of atherosclerotic plaque en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/heartjnl-2012-303440
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.04
dc.relation.issn 1468-201X


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