Universidad Peruana Cayetano Heredia

Mammary analogue secretory carcinoma of salivary glands is a lipid-rich tumour, and adipophilin can be valuable in its identification

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dc.contributor.author Mariano, Fernanda Viviane
dc.contributor.author dos Santos, Harim Tavares
dc.contributor.author Azañero, Wilson Delgado
dc.contributor.author da Cunha, Isabela Werneck
dc.contributor.author Coutinho-Camilo, Claudia Malheiros
dc.contributor.author de Almeida, Oslei Paes
dc.contributor.author Kowalski, Luiz Paulo
dc.contributor.author Altemani, Albina
dc.date.accessioned 2022-01-04T20:29:59Z
dc.date.available 2022-01-04T20:29:59Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10498
dc.description.abstract Aims: Mammary analogue secretory carcinoma (MASC) of salivary glands shows morphological similarities to milk-secreting mammary epithelial cells. The aim of this study was to analyse the immunohistochemical expression of adipophilin (a component of milk lipid globule membranes) and of proteins related to secretory mechanisms (STAT5a and mammaglobin) in MASC and other salivary tumours. Methods: and results: Ten cases of MASC (all with ETV6 translocation) and 83 other salivary carcinomas were studied. In all MASC cases, adipophilin stained numerous large lipid droplets. These droplets were minute in other salivary carcinomas, except for sebaceous carcinoma. Overexpression of STAT5a was detected in all MASC cases, but only occasionally in other carcinomas. Mammaglobin expression occurred frequently in MASC (70% of cases), whereas, in other carcinomas, it was uncommon and limited. Only MASC showed cytoplasmic reactivity for p63, particularly in papillary–cystic areas. Positivity for S100, vimentin and high molecular weight keratin was observed in 100% of MASC cases. Conclusions: MASC is a lipid-rich tumour containing large lipid droplets covered by adipophilin. This finding can be included among its defining immunohistochemical features, and possibly represents lactation-like secretory differentiation. Strong expression of STAT5a and cytoplasmic p63 in MASC reinforces this hypothesis. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Histopathology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adipophilin en_US
dc.subject lipid-rich tumour en_US
dc.subject mammary analogue secretory carcinoma en_US
dc.title Mammary analogue secretory carcinoma of salivary glands is a lipid-rich tumour, and adipophilin can be valuable in its identification en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/his.12192
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.relation.issn 1365-2559


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