Universidad Peruana Cayetano Heredia

Treatment outcomes of human bartonellosis: A systematic review and meta-analysis

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dc.contributor.author Prutsky, Gabriela
dc.contributor.author Domecq, Juan Pablo
dc.contributor.author Mori, Laura
dc.contributor.author Bebko, Serge
dc.contributor.author Matzumura, Melissa
dc.contributor.author Sabouni, Amar
dc.contributor.author Shahrour, Anas
dc.contributor.author Erwin, Patricia J.
dc.contributor.author Boyce, Thomas G.
dc.contributor.author Montori, Victor M.
dc.contributor.author Málaga Rodríguez, Germán Javier
dc.contributor.author Murad, M. Hassan
dc.date.accessioned 2022-01-04T20:30:00Z
dc.date.available 2022-01-04T20:30:00Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10516
dc.description.abstract Bartonella henselae, Bartonella quintana, and Bartonella bacilliformis are responsible for the majority of cases of bartonellosis in humans. These species have various unique epidemiologic characteristics, clinical manifestations, and treatment approaches. The Objetive: of this study was to summarize the evidence on the treatment for the three most common species of Bartonella in humans. We searched electronic databases through August 2011 for randomized controlled trials and observational studies designed to evaluate the efficacy and safety of the regimens used to treat diseases produced by B. henselae, B. quintana, and B. bacilliformis. Study selection and appraisal were done in duplicate. We found two randomized and seven non-randomized studies at high risk of bias. For cat scratch disease, antibiotics did not significantly affect the cure rate or time to achieve cure. In chronic bacteremia, gentamicin and doxycycline significantly increased the resolution rate. The recommended treatment was not better than other regimens for infectious endocarditis and bacillary angiomatosis. Current clinical practice for the treatment of bartonellosis relies mostly on expert opinion and antimicrobial susceptibility data. Randomized controlled trials are needed in the field to compare different treatment options. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries International Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Bartonellosis en_US
dc.subject Bartonella henselae en_US
dc.subject Bartonella quintana en_US
dc.subject Bartonella bacilliformis en_US
dc.subject Cat scratch disease en_US
dc.subject Bacillary angiomatosis en_US
dc.subject Antibiotic treatment en_US
dc.title Treatment outcomes of human bartonellosis: A systematic review and meta-analysis en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1016/j.ijid.2013.02.016
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1878-3511


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