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dc.contributor.author | Mayer, Erick F. | |
dc.contributor.author | Ita, Fanny | |
dc.contributor.author | Gonzalez, Elsa | |
dc.contributor.author | Verdonck, Kristien | |
dc.contributor.author | Bravo Puccio, Francisco Gerardo | |
dc.contributor.author | Clark, Daniel | |
dc.contributor.author | Gotuzzo Herencia, José Eduardo | |
dc.date.accessioned | 2022-01-04T20:30:00Z | |
dc.date.available | 2022-01-04T20:30:00Z | |
dc.date.issued | 2013 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/10517 | |
dc.description.abstract | To assess the association between human T-lymphotropic virus type 1 (HTLV-1) infection and onychodystrophy. This was a cross-sectional study. At our institute, we provide HTLV-1 testing to relatives of HTLV-1-infected people and patients with suspected HTLV-1-associated diseases. The diagnosis of onychodystrophy was made clinically before testing for HTLV-1; the number and distribution of affected nails was registered. We assessed the association between onychodystrophy and HTLV-1 through bi- and multivariable analyses. Logistic regression was used to adjust for age, sex, and indication for HTLV-1 testing, using six affected nails (90th percentile) as the cut-off point. Between April 2006 and March 2008, we included 893 subjects; their mean age was 38 years (standard deviation 19 years), and 527 (59%) were women. Onychodystrophy of one or more nails was observed in 323 participants (36%), and 236 subjects (26%) were HTLV-1-positive. The median number of affected nails was higher in HTLV-1-positive than in HTLV-1-negative subjects (Mann–Whitney test, p < 0.001). Thirty-eight of 97 subjects with six or more affected nails (39%) were HTLV-1-infected, compared to 198 of 796 subjects with fewer than six affected nails (25%) (crude OR 1.9, 95% confidence interval (CI) 1.2–3.1; p = 0.003). This association remained significant in the multiple logistic regression model (adjusted OR 2.0, 95% CI 1.2–3.3; p = 0.005). There is an independent association between HTLV-1 infection and onychodystrophy. Patients with an HTLV-1 infection might have a higher risk for onychomycosis given the abnormal nail plate and a decreased T-cell-mediated immunologic response. | en_US |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofseries | International Journal of Infectious Diseases | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Cross-sectional study | en_US |
dc.subject | Human T-lymphotropic virus type 1 | en_US |
dc.subject | Onychodystrophy | en_US |
dc.subject | Peru | en_US |
dc.title | Association between onychodystrophy and human T-lymphotropic virus type 1 infection | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1016/j.ijid.2012.11.009 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.08 | |
dc.relation.issn | 1878-3511 |
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