Universidad Peruana Cayetano Heredia

Is atherosclerosis fundamental to human aging? Lessons from ancient mummies

Mostrar el registro sencillo del ítem

dc.contributor.author Clarke, Emily M.
dc.contributor.author Thompson, Randall C.
dc.contributor.author Allam, Adel H.
dc.contributor.author Wann, L. Samuel
dc.contributor.author Lombardi, Guido P.
dc.contributor.author Sutherland, M. Linda
dc.contributor.author Sutherland, James D.
dc.contributor.author Cox, Samantha L.
dc.contributor.author Soliman, Muhammad Al-Tohamy
dc.contributor.author Abd el-Maksoud, Gomaa
dc.contributor.author Badr, Ibrahem
dc.contributor.author Miyamoto, Michael I.
dc.contributor.author Frohlich, Bruno
dc.contributor.author Nur el-din, Abdel-Halim
dc.contributor.author Stewart, Alexandre F. R.
dc.contributor.author Narula, Jagat
dc.contributor.author Zink, Albert R.
dc.contributor.author Finch, Caleb E.
dc.contributor.author Michalik, David E.
dc.contributor.author Thomas, Gregory S.
dc.date.accessioned 2022-01-04T20:30:01Z
dc.date.available 2022-01-04T20:30:01Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/10539
dc.description.abstract Case reports from Johan Czermak, Marc Ruffer, and others a century or more ago demonstrated ancient Egyptians had atherosclerosis three millennia ago. The Horus study team extended their findings, demonstrating that atherosclerosis was prevalent among 76 ancient Egyptian mummies and among 61 mummies from each of the ancient cultures of Peru, the American Southwest, and the Aleutian Islands. These findings challenge the assumption that atherosclerosis is a modern disease caused by present day risk factors. An extensive autopsy of an ancient Egyptian teenage male weaver named Nakht found that he was infected with four parasites: Schistosoma haematobium, Taenia species, Trichinella spiralis, and Plasmodium falciparum. Modern day patients with chronic inflammatory disease such as rheumatoid arthritis, systemic lupus erythematosus, and human immunodeficiency virus experience premature atherosclerosis. Could the burden of chronic inflammatory disease have been a risk factor for atherosclerosis in these ancient cultures? The prevalence of atherosclerosis in four diverse ancient cultures is consistent with atherosclerosis being fundamental to aging. The impact of risk factors in modern times, and potentially in ancient times, suggests a strong gene-environmental interplay: human genes provide a vulnerability to atherosclerosis, the environment determines when and if atherosclerosis becomes manifest clinically. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of Cardiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Mummies en_US
dc.subject Atherosclerosis en_US
dc.subject Aging en_US
dc.subject Paleopathology en_US
dc.subject Coronary artery disease en_US
dc.title Is atherosclerosis fundamental to human aging? Lessons from ancient mummies en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jjcc.2013.12.012
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.27
dc.relation.issn 0914-5087


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas