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Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100-299 μg/L: A UNICEF/ICCIDD study group report

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dc.contributor.author Zimmermann, Michael B.
dc.contributor.author Aeberli, Isabelle
dc.contributor.author Andersson, Maria
dc.contributor.author Assey, Vincent
dc.contributor.author Yorg, Jorge A.Jara
dc.contributor.author Jooste, Pieter
dc.contributor.author Jukić, Tomislav
dc.contributor.author Kartono, Djoko
dc.contributor.author Kusić, Zvonko
dc.contributor.author Pretell, Eduardo
dc.contributor.author Luis Jr., Teofilo O.L.San
dc.contributor.author Juliawati Untoro
dc.contributor.author Timmer, Arnold
dc.date.accessioned 2022-01-04T20:30:01Z
dc.date.available 2022-01-04T20:30:01Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10542
dc.description.abstract Context: The median urinary iodine concentration (UIC) is a biomarker of iodine intake. According to the World Health Organization, a median UIC in the range 100–199 μg/L indicates adequate and 200–299 μg/L more than adequate intake. Thyroglobulin (Tg) may be a promising functional biomarker of both iodine deficiency and excess. Objectives: Using a standardized dried blood spots-Tg assay in children, we evaluated the Tg response to both low- and high-iodine intake and estimated the population cutoff point for iodine deficiency or excess. Also, we compared thyroid functions within the UIC ranges of 100–199 vs 200–299 μg/L. Design and Setting: We conducted a cross-sectional study in primary schools in 12 countries. Subjects: Subjects were 6 to 12 years old (n = 2512). Main Outcome Measures: We measured UIC, TSH, total T4, Tg, and thyroid antibodies. Results: Over a range of iodine intakes from severely deficient to excessive, Tg concentrations showed a clear U-shaped curve. Compared with iodine-sufficient children, there was a significantly higher prevalence of elevated Tg values in children with iodine deficiency (UIC <100 μg/L) and iodine excess (UIC >300 μg/L). There was no significant change in the prevalence of elevated Tg, TSH, T4, or thyroid antibodies comparing children within the UIC ranges of 100–199 vs 200–299 μg/L. Conclusions: In school-aged children, 1) Tg is a sensitive indicator of both low and excess iodine intake; 2) a median Tg of <13 μg/L and/or <3% of Tg values >40 μg/L indicates iodine sufficiency in the population; 3) the acceptable range of median UIC in monitoring iodized salt programs could be widened to a single category of sufficient iodine intake from 100 to 299 μg/L. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Journal of Clinical Endocrinology and Metabolism
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Cross-Sectional Studies en_US
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject prevalence en_US
dc.subject South Africa en_US
dc.subject Biological Markers en_US
dc.subject Seroepidemiologic Studies en_US
dc.subject World Health en_US
dc.subject disease severity en_US
dc.subject Sodium Chloride, Dietary en_US
dc.subject iodine en_US
dc.subject Iodine en_US
dc.subject urinalysis en_US
dc.subject Paraguay en_US
dc.subject United Nations en_US
dc.subject sodium chloride en_US
dc.subject urine level en_US
dc.subject Tanzania en_US
dc.subject Indonesia en_US
dc.subject dried blood spot testing en_US
dc.subject Dried Blood Spot Testing en_US
dc.subject food intake en_US
dc.subject Philippines en_US
dc.subject China en_US
dc.subject Autoantibodies en_US
dc.subject Bahrain en_US
dc.subject Croatia en_US
dc.subject hypothyroidism en_US
dc.subject iodine deficiency en_US
dc.subject iodine excess en_US
dc.subject Morocco en_US
dc.subject nutritional disorder en_US
dc.subject primary school en_US
dc.subject subclinical hyperthyroidism en_US
dc.subject Switzerland en_US
dc.subject Tajikistan en_US
dc.subject thyroglobulin en_US
dc.subject Thyroglobulin en_US
dc.subject thyroid antibody en_US
dc.subject thyroid function en_US
dc.subject Thyroid Gland en_US
dc.subject thyroxine en_US
dc.subject Trace Elements en_US
dc.title Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100-299 μg/L: A UNICEF/ICCIDD study group report en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1210/jc.2012-3952
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18
dc.relation.issn 1945-7197


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