dc.contributor.author |
Zimmermann, Michael B. |
|
dc.contributor.author |
Aeberli, Isabelle |
|
dc.contributor.author |
Andersson, Maria |
|
dc.contributor.author |
Assey, Vincent |
|
dc.contributor.author |
Yorg, Jorge A.Jara |
|
dc.contributor.author |
Jooste, Pieter |
|
dc.contributor.author |
Jukić, Tomislav |
|
dc.contributor.author |
Kartono, Djoko |
|
dc.contributor.author |
Kusić, Zvonko |
|
dc.contributor.author |
Pretell, Eduardo |
|
dc.contributor.author |
Luis Jr., Teofilo O.L.San |
|
dc.contributor.author |
Juliawati Untoro |
|
dc.contributor.author |
Timmer, Arnold |
|
dc.date.accessioned |
2022-01-04T20:30:01Z |
|
dc.date.available |
2022-01-04T20:30:01Z |
|
dc.date.issued |
2013 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/10542 |
|
dc.description.abstract |
Context: The median urinary iodine concentration (UIC) is a biomarker of iodine intake. According to the World Health Organization, a median UIC in the range 100–199 μg/L indicates adequate and 200–299 μg/L more than adequate intake. Thyroglobulin (Tg) may be a promising functional biomarker of both iodine deficiency and excess. Objectives: Using a standardized dried blood spots-Tg assay in children, we evaluated the Tg response to both low- and high-iodine intake and estimated the population cutoff point for iodine deficiency or excess. Also, we compared thyroid functions within the UIC ranges of 100–199 vs 200–299 μg/L. Design and Setting: We conducted a cross-sectional study in primary schools in 12 countries. Subjects: Subjects were 6 to 12 years old (n = 2512). Main Outcome Measures: We measured UIC, TSH, total T4, Tg, and thyroid antibodies. Results: Over a range of iodine intakes from severely deficient to excessive, Tg concentrations showed a clear U-shaped curve. Compared with iodine-sufficient children, there was a significantly higher prevalence of elevated Tg values in children with iodine deficiency (UIC <100 μg/L) and iodine excess (UIC >300 μg/L). There was no significant change in the prevalence of elevated Tg, TSH, T4, or thyroid antibodies comparing children within the UIC ranges of 100–199 vs 200–299 μg/L. Conclusions: In school-aged children, 1) Tg is a sensitive indicator of both low and excess iodine intake; 2) a median Tg of <13 μg/L and/or <3% of Tg values >40 μg/L indicates iodine sufficiency in the population; 3) the acceptable range of median UIC in monitoring iodized salt programs could be widened to a single category of sufficient iodine intake from 100 to 299 μg/L. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Oxford University Press |
|
dc.relation.ispartofseries |
Journal of Clinical Endocrinology and Metabolism |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Cross-Sectional Studies |
en_US |
dc.subject |
Humans |
en_US |
dc.subject |
Peru |
en_US |
dc.subject |
prevalence |
en_US |
dc.subject |
South Africa |
en_US |
dc.subject |
Biological Markers |
en_US |
dc.subject |
Seroepidemiologic Studies |
en_US |
dc.subject |
World Health |
en_US |
dc.subject |
disease severity |
en_US |
dc.subject |
Sodium Chloride, Dietary |
en_US |
dc.subject |
iodine |
en_US |
dc.subject |
Iodine |
en_US |
dc.subject |
urinalysis |
en_US |
dc.subject |
Paraguay |
en_US |
dc.subject |
United Nations |
en_US |
dc.subject |
sodium chloride |
en_US |
dc.subject |
urine level |
en_US |
dc.subject |
Tanzania |
en_US |
dc.subject |
Indonesia |
en_US |
dc.subject |
dried blood spot testing |
en_US |
dc.subject |
Dried Blood Spot Testing |
en_US |
dc.subject |
food intake |
en_US |
dc.subject |
Philippines |
en_US |
dc.subject |
China |
en_US |
dc.subject |
Autoantibodies |
en_US |
dc.subject |
Bahrain |
en_US |
dc.subject |
Croatia |
en_US |
dc.subject |
hypothyroidism |
en_US |
dc.subject |
iodine deficiency |
en_US |
dc.subject |
iodine excess |
en_US |
dc.subject |
Morocco |
en_US |
dc.subject |
nutritional disorder |
en_US |
dc.subject |
primary school |
en_US |
dc.subject |
subclinical hyperthyroidism |
en_US |
dc.subject |
Switzerland |
en_US |
dc.subject |
Tajikistan |
en_US |
dc.subject |
thyroglobulin |
en_US |
dc.subject |
Thyroglobulin |
en_US |
dc.subject |
thyroid antibody |
en_US |
dc.subject |
thyroid function |
en_US |
dc.subject |
Thyroid Gland |
en_US |
dc.subject |
thyroxine |
en_US |
dc.subject |
Trace Elements |
en_US |
dc.title |
Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100-299 μg/L: A UNICEF/ICCIDD study group report |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1210/jc.2012-3952 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.02.18 |
|
dc.relation.issn |
1945-7197 |
|