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dc.contributor.author | Zimmermann, Michael B. | |
dc.contributor.author | Aeberli, Isabelle | |
dc.contributor.author | Andersson, Maria | |
dc.contributor.author | Assey, Vincent | |
dc.contributor.author | Yorg, Jorge A.Jara | |
dc.contributor.author | Jooste, Pieter | |
dc.contributor.author | Jukić, Tomislav | |
dc.contributor.author | Kartono, Djoko | |
dc.contributor.author | Kusić, Zvonko | |
dc.contributor.author | Pretell, Eduardo | |
dc.contributor.author | Luis Jr., Teofilo O.L.San | |
dc.contributor.author | Juliawati Untoro | |
dc.contributor.author | Timmer, Arnold | |
dc.date.accessioned | 2022-01-04T20:30:01Z | |
dc.date.available | 2022-01-04T20:30:01Z | |
dc.date.issued | 2013 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/10542 | |
dc.description.abstract | Context: The median urinary iodine concentration (UIC) is a biomarker of iodine intake. According to the World Health Organization, a median UIC in the range 100–199 μg/L indicates adequate and 200–299 μg/L more than adequate intake. Thyroglobulin (Tg) may be a promising functional biomarker of both iodine deficiency and excess. Objectives: Using a standardized dried blood spots-Tg assay in children, we evaluated the Tg response to both low- and high-iodine intake and estimated the population cutoff point for iodine deficiency or excess. Also, we compared thyroid functions within the UIC ranges of 100–199 vs 200–299 μg/L. Design and Setting: We conducted a cross-sectional study in primary schools in 12 countries. Subjects: Subjects were 6 to 12 years old (n = 2512). Main Outcome Measures: We measured UIC, TSH, total T4, Tg, and thyroid antibodies. Results: Over a range of iodine intakes from severely deficient to excessive, Tg concentrations showed a clear U-shaped curve. Compared with iodine-sufficient children, there was a significantly higher prevalence of elevated Tg values in children with iodine deficiency (UIC <100 μg/L) and iodine excess (UIC >300 μg/L). There was no significant change in the prevalence of elevated Tg, TSH, T4, or thyroid antibodies comparing children within the UIC ranges of 100–199 vs 200–299 μg/L. Conclusions: In school-aged children, 1) Tg is a sensitive indicator of both low and excess iodine intake; 2) a median Tg of <13 μg/L and/or <3% of Tg values >40 μg/L indicates iodine sufficiency in the population; 3) the acceptable range of median UIC in monitoring iodized salt programs could be widened to a single category of sufficient iodine intake from 100 to 299 μg/L. | en_US |
dc.language.iso | eng | |
dc.publisher | Oxford University Press | |
dc.relation.ispartofseries | Journal of Clinical Endocrinology and Metabolism | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Cross-Sectional Studies | en_US |
dc.subject | Humans | en_US |
dc.subject | Peru | en_US |
dc.subject | prevalence | en_US |
dc.subject | South Africa | en_US |
dc.subject | Biological Markers | en_US |
dc.subject | Seroepidemiologic Studies | en_US |
dc.subject | World Health | en_US |
dc.subject | disease severity | en_US |
dc.subject | Sodium Chloride, Dietary | en_US |
dc.subject | iodine | en_US |
dc.subject | Iodine | en_US |
dc.subject | urinalysis | en_US |
dc.subject | Paraguay | en_US |
dc.subject | United Nations | en_US |
dc.subject | sodium chloride | en_US |
dc.subject | urine level | en_US |
dc.subject | Tanzania | en_US |
dc.subject | Indonesia | en_US |
dc.subject | dried blood spot testing | en_US |
dc.subject | Dried Blood Spot Testing | en_US |
dc.subject | food intake | en_US |
dc.subject | Philippines | en_US |
dc.subject | China | en_US |
dc.subject | Autoantibodies | en_US |
dc.subject | Bahrain | en_US |
dc.subject | Croatia | en_US |
dc.subject | hypothyroidism | en_US |
dc.subject | iodine deficiency | en_US |
dc.subject | iodine excess | en_US |
dc.subject | Morocco | en_US |
dc.subject | nutritional disorder | en_US |
dc.subject | primary school | en_US |
dc.subject | subclinical hyperthyroidism | en_US |
dc.subject | Switzerland | en_US |
dc.subject | Tajikistan | en_US |
dc.subject | thyroglobulin | en_US |
dc.subject | Thyroglobulin | en_US |
dc.subject | thyroid antibody | en_US |
dc.subject | thyroid function | en_US |
dc.subject | Thyroid Gland | en_US |
dc.subject | thyroxine | en_US |
dc.subject | Trace Elements | en_US |
dc.title | Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100-299 μg/L: A UNICEF/ICCIDD study group report | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1210/jc.2012-3952 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.18 | |
dc.relation.issn | 1945-7197 |
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