dc.contributor.author |
Reyes-Reyes, E.M. |
|
dc.contributor.author |
Jin, Z. |
|
dc.contributor.author |
Vaisberg Wollach, Abraham Jaime |
|
dc.contributor.author |
Hammond, G.B. |
|
dc.contributor.author |
Bates, P.J. |
|
dc.date.accessioned |
2022-01-04T20:31:43Z |
|
dc.date.available |
2022-01-04T20:31:43Z |
|
dc.date.issued |
2013 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/10567 |
|
dc.description.abstract |
Recently, our group reported the discovery of three new withanolides, physangulidines A–C, from Physalis angulata. In this study, the biological effects of physangulidine A (1), which was the most active and abundant of the three new constituents, are described. It was found that 1 significantly reduces survival in clonogenic assays for two hormone-independent prostate cancer cell lines. Flow cytometry and confocal microscopy studies in DU145 human prostate cancer cells indicated that 1 induces cell cycle arrest in the G2/M phase and causes defective mitosis. It was determined also that 1 produces programed cell death by apoptosis, as evidenced by biochemical markers and distinct changes in cell morphology. These results imply that the antimitotic and proapoptotic effects of 1 may contribute significantly to the biological activities and potential medicinal properties of its plant of origin. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
American Chemical Society |
|
dc.relation.ispartofseries |
Journal of Natural Products |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
unclassified drug |
en_US |
dc.subject |
Humans |
en_US |
dc.subject |
human cell |
en_US |
dc.subject |
medicinal plant |
en_US |
dc.subject |
confocal microscopy |
en_US |
dc.subject |
flow cytometry |
en_US |
dc.subject |
cell death |
en_US |
dc.subject |
mitosis |
en_US |
dc.subject |
antineoplastic activity |
en_US |
dc.subject |
apoptosis |
en_US |
dc.subject |
Antineoplastic Agents |
en_US |
dc.subject |
Apoptosis |
en_US |
dc.subject |
cancer cell |
en_US |
dc.subject |
cell cycle G2 phase |
en_US |
dc.subject |
cell cycle M phase |
en_US |
dc.subject |
Cell Division |
en_US |
dc.subject |
cell structure |
en_US |
dc.subject |
Drug Screening Assays, Antitumor |
en_US |
dc.subject |
G2 Phase |
en_US |
dc.subject |
Microscopy, Confocal |
en_US |
dc.subject |
Molecular Structure |
en_US |
dc.subject |
Physalis |
en_US |
dc.subject |
Physalis angulata |
en_US |
dc.subject |
physangulidine a |
en_US |
dc.subject |
prostate cancer |
en_US |
dc.subject |
Prostatic Neoplasms |
en_US |
dc.subject |
withanolide |
en_US |
dc.subject |
Withanolides |
en_US |
dc.title |
Physangulidine A, a withanolide from Physalis angulata, perturbs the cell cycle and induces cell death by apoptosis in prostate cancer cells |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1021/np300457g |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.02.21 |
|
dc.relation.issn |
1520-6025 |
|