Universidad Peruana Cayetano Heredia
Physangulidine A, a withanolide from Physalis angulata, perturbs the cell cycle and induces cell death by apoptosis in prostate cancer cells
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| dc.contributor.author | Reyes-Reyes, E.M. | |
| dc.contributor.author | Jin, Z. | |
| dc.contributor.author | Vaisberg Wollach, Abraham Jaime | |
| dc.contributor.author | Hammond, G.B. | |
| dc.contributor.author | Bates, P.J. | |
| dc.date.accessioned | 2022-01-04T20:31:43Z | |
| dc.date.available | 2022-01-04T20:31:43Z | |
| dc.date.issued | 2013 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/10567 | |
| dc.description.abstract | Recently, our group reported the discovery of three new withanolides, physangulidines A–C, from Physalis angulata. In this study, the biological effects of physangulidine A (1), which was the most active and abundant of the three new constituents, are described. It was found that 1 significantly reduces survival in clonogenic assays for two hormone-independent prostate cancer cell lines. Flow cytometry and confocal microscopy studies in DU145 human prostate cancer cells indicated that 1 induces cell cycle arrest in the G2/M phase and causes defective mitosis. It was determined also that 1 produces programed cell death by apoptosis, as evidenced by biochemical markers and distinct changes in cell morphology. These results imply that the antimitotic and proapoptotic effects of 1 may contribute significantly to the biological activities and potential medicinal properties of its plant of origin. | en_US |
| dc.language.iso | eng | |
| dc.publisher | American Chemical Society | |
| dc.relation.ispartofseries | Journal of Natural Products | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | unclassified drug | en_US |
| dc.subject | Humans | en_US |
| dc.subject | human cell | en_US |
| dc.subject | medicinal plant | en_US |
| dc.subject | confocal microscopy | en_US |
| dc.subject | flow cytometry | en_US |
| dc.subject | cell death | en_US |
| dc.subject | mitosis | en_US |
| dc.subject | antineoplastic activity | en_US |
| dc.subject | apoptosis | en_US |
| dc.subject | Antineoplastic Agents | en_US |
| dc.subject | Apoptosis | en_US |
| dc.subject | cancer cell | en_US |
| dc.subject | cell cycle G2 phase | en_US |
| dc.subject | cell cycle M phase | en_US |
| dc.subject | Cell Division | en_US |
| dc.subject | cell structure | en_US |
| dc.subject | Drug Screening Assays, Antitumor | en_US |
| dc.subject | G2 Phase | en_US |
| dc.subject | Microscopy, Confocal | en_US |
| dc.subject | Molecular Structure | en_US |
| dc.subject | Physalis | en_US |
| dc.subject | Physalis angulata | en_US |
| dc.subject | physangulidine a | en_US |
| dc.subject | prostate cancer | en_US |
| dc.subject | Prostatic Neoplasms | en_US |
| dc.subject | withanolide | en_US |
| dc.subject | Withanolides | en_US |
| dc.title | Physangulidine A, a withanolide from Physalis angulata, perturbs the cell cycle and induces cell death by apoptosis in prostate cancer cells | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1021/np300457g | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.21 | |
| dc.relation.issn | 1520-6025 |
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