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Fast-twitch glycolytic skeletal muscle is predisposed to age-induced impairments in mitochondrial function

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dc.contributor.author Jacobs, Robert A.
dc.contributor.author Díaz, Víctor
dc.contributor.author Soldini, Lavinia
dc.contributor.author Haider, Thomas
dc.contributor.author Thomassen, Martin
dc.contributor.author Nordsborg, Nikolai B.
dc.contributor.author Gassmann, Max
dc.contributor.author Lundby, Carsten
dc.date.accessioned 2022-01-04T20:31:44Z
dc.date.available 2022-01-04T20:31:44Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10580
dc.description.abstract The etiology of mammalian senescence is suggested to involve the progressive impairment of mitochondrial function; however, direct observations of age-induced alterations in actual respiratory chain function are lacking. Accordingly, we assessed mitochondrial function via high-resolution respirometry and mitochondrial protein expression in soleus, quadricep, and lateral gastrocnemius skeletal muscles, which represent type 1 slow-twitch oxidative muscle (soleus) and type 2 fast-twitch glycolytic muscle (quadricep and gastrocnemius), respectively, in young (10–12 weeks) and mature (74–76 weeks) mice. Electron transport through mitochondrial complexes I and III increases with age in quadricep and gastrocnemius, which is not observed in soleus. Mitochondrial coupling efficiency during respiration through complex I also deteriorates with age in gastrocnemius and shows a tendency (p = .085) to worsen in quadricep. These data demonstrate actual alterations in electron transport function that occurs with age and are dependent on skeletal muscle type. en_US
dc.language.iso eng
dc.publisher Gerontological Society of America
dc.relation.ispartofseries Journals of Gerontology - Series A Biological Sciences and Medical Sciences
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Mitochondria en_US
dc.subject Respiratory chain en_US
dc.subject Function theory of aging en_US
dc.title Fast-twitch glycolytic skeletal muscle is predisposed to age-induced impairments in mitochondrial function en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/gerona/gls335
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.26
dc.relation.issn 1758-535X


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