dc.contributor.author |
Jacobs, Robert A. |
|
dc.contributor.author |
Díaz, Víctor |
|
dc.contributor.author |
Soldini, Lavinia |
|
dc.contributor.author |
Haider, Thomas |
|
dc.contributor.author |
Thomassen, Martin |
|
dc.contributor.author |
Nordsborg, Nikolai B. |
|
dc.contributor.author |
Gassmann, Max |
|
dc.contributor.author |
Lundby, Carsten |
|
dc.date.accessioned |
2022-01-04T20:31:44Z |
|
dc.date.available |
2022-01-04T20:31:44Z |
|
dc.date.issued |
2013 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/10580 |
|
dc.description.abstract |
The etiology of mammalian senescence is suggested to involve the progressive impairment of mitochondrial function; however, direct observations of age-induced alterations in actual respiratory chain function are lacking. Accordingly, we assessed mitochondrial function via high-resolution respirometry and mitochondrial protein expression in soleus, quadricep, and lateral gastrocnemius skeletal muscles, which represent type 1 slow-twitch oxidative muscle (soleus) and type 2 fast-twitch glycolytic muscle (quadricep and gastrocnemius), respectively, in young (10–12 weeks) and mature (74–76 weeks) mice. Electron transport through mitochondrial complexes I and III increases with age in quadricep and gastrocnemius, which is not observed in soleus. Mitochondrial coupling efficiency during respiration through complex I also deteriorates with age in gastrocnemius and shows a tendency (p = .085) to worsen in quadricep. These data demonstrate actual alterations in electron transport function that occurs with age and are dependent on skeletal muscle type. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Gerontological Society of America |
|
dc.relation.ispartofseries |
Journals of Gerontology - Series A Biological Sciences and Medical Sciences |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Mitochondria |
en_US |
dc.subject |
Respiratory chain |
en_US |
dc.subject |
Function theory of aging |
en_US |
dc.title |
Fast-twitch glycolytic skeletal muscle is predisposed to age-induced impairments in mitochondrial function |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1093/gerona/gls335 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.02.26 |
|
dc.relation.issn |
1758-535X |
|