Universidad Peruana Cayetano Heredia

Assessing malaria transmission in a low endemicity area of north-western Peru

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dc.contributor.author Rosas-Aguirre, Angel
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Speybroeck, Niko
dc.contributor.author Cook, Jackie
dc.contributor.author Contreras-Mancilla, Juan
dc.contributor.author Soto, Veronica
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Pozo, Edwar
dc.contributor.author Ponce, Oscar J.
dc.contributor.author Pereira, Mayne O.
dc.contributor.author Soares, Irene S.
dc.contributor.author Theisen, Michael
dc.contributor.author D'Alessandro, Umberto
dc.contributor.author Erhart, Annette
dc.date.accessioned 2022-01-04T20:31:45Z
dc.date.available 2022-01-04T20:31:45Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10598
dc.description.abstract Background: Where malaria endemicity is low, control programmes need increasingly sensitive tools for monitoring malaria transmission intensity (MTI) and to better define health priorities. A cross-sectional survey was conducted in a low endemicity area of the Peruvian north-western coast to assess the MTI using both molecular and serological tools. Methods: Epidemiological, parasitological and serological data were collected from 2,667 individuals in three settlements of Bellavista district, in May 2010. Parasite infection was detected using microscopy and polymerase chain reaction (PCR). Antibodies to Plasmodium vivax merozoite surface protein-119 (PvMSP119) and to Plasmodium falciparum glutamate-rich protein (PfGLURP) were detected by ELISA. Risk factors for exposure to malaria (seropositivity) were assessed by multivariate survey logistic regression models. Age-specific antibody prevalence of both P. falciparum and P. vivax were analysed using a previously published catalytic conversion model based on maximum likelihood for generating seroconversion rates (SCR). Results: The overall parasite prevalence by microscopy and PCR were extremely low: 0.3 and 0.9%, respectively for P. vivax, and 0 and 0.04%, respectively for P. falciparum, while seroprevalence was much higher, 13.6% for P. vivax and 9.8% for P. falciparum. Settlement, age and occupation as moto-taxi driver during previous year were significantly associated with P. falciparum exposure, while age and distance to the water drain were associated with P. vivax exposure. Likelihood ratio tests supported age seroprevalence curves with two SCR for both P. vivax and P. falciparum indicating significant changes in the MTI over time. The SCR for PfGLURP was 19-fold lower after 2002 as compared to before (λ1 = 0.022 versus λ2 = 0.431), and the SCR for PvMSP119 was four-fold higher after 2006 as compared to before (λ1 = 0.024 versus λ2 = 0.006). Conclusion: Combining molecular and serological tools considerably enhanced the capacity of detecting current and past exposure to malaria infections and related risks factors in this very low endemicity area. This allowed for an improved characterization of the current human reservoir of infections, largely hidden and heterogeneous, as well as providing insights into recent changes in species specific MTIs. This approach will be of key importance for evaluating and monitoring future malaria elimination strategies. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries Malaria Journal
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Cross-Sectional Studies en_US
dc.subject Humans en_US
dc.subject Polymerase Chain Reaction en_US
dc.subject Infant, Newborn en_US
dc.subject Enzyme-Linked Immunosorbent Assay en_US
dc.subject Peru en_US
dc.subject Antibodies en_US
dc.subject DNA en_US
dc.subject Malaria, Falciparum en_US
dc.subject Malaria, Vivax en_US
dc.subject Plasmodium falciparum en_US
dc.subject Plasmodium vivax en_US
dc.title Assessing malaria transmission in a low endemicity area of north-western Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/1475-2875-12-339
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1475-2875


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