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Immunohistochemical expression of Skp2 protein in oral nevi and melanoma

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dc.contributor.author Benevenuto-de-Andrade, Bruno-Augusto
dc.contributor.author León, Jorge-Esquiche
dc.contributor.author Carlos, Román
dc.contributor.author Delgado-Azañero, Wilson
dc.contributor.author Mosqueda-Taylor, Adalberto
dc.contributor.author Paes-de-Almeida, Oslei
dc.date.accessioned 2022-01-04T20:31:45Z
dc.date.available 2022-01-04T20:31:45Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10603
dc.description.abstract Objective: The aim of this study was to analyze the immunohistochemical expression of Skp2 protein in 38 oral nevi and 11 primary oral melanomas. Study Design: Expression of this ubiquitin protein was evaluated by immunohistochemistry in 49 oral melanocytic lesions, including 38 intramucosal nevi and 11 primary oral melanomas. The labeling index (LI) was assessed considering the percentage of cells expressing nuclear positivity out of the total number of cells, counting 1000 cells per slide. Results: Skp2 protein was rarely expressed in intramucosal nevi, in contrast to oral melanomas, which showed high levels of this protein. Conclusion: These results indicate that Skp2 protein may play a role in the development and progression of oral melanomas, and it also could be useful as an immunohistochemical marker for differential diagnosis of oral benign and malignant melanocytic lesions. en_US
dc.language.iso eng
dc.publisher Medicina Oral
dc.relation.ispartofseries Medicina Oral, Patologia Oral y Cirugia Bucal
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Oral melanoma en_US
dc.subject oral nevi en_US
dc.subject Skp2 en_US
dc.subject cell cycle en_US
dc.subject immunohistochemistry en_US
dc.title Immunohistochemical expression of Skp2 protein in oral nevi and melanoma en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4317/medoral.18781
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.14
dc.relation.issn 1698-6946


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