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dc.contributor.author Lehmann, Jason .S.
dc.contributor.author Matthias, Michael A.
dc.contributor.author Vinetz, Joseph Michael
dc.contributor.author Fouts, Derrick E.
dc.date.accessioned 2022-01-04T20:31:46Z
dc.date.available 2022-01-04T20:31:46Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/20.500.12866/10633
dc.description.abstract Leptospirosis, caused by pathogenic spirochetes belonging to the genus Leptospira, is a zoonosis with important impacts on human and animal health worldwide. Research on the mechanisms of Leptospira pathogenesis has been hindered due to slow growth of infectious strains, poor transformability, and a paucity of genetic tools. As a Results: of second generation sequencing technologies, there has been an acceleration of leptospiral genome sequencing efforts in the past decade, which has enabled a concomitant increase in functional genomics analyses of Leptospira pathogenesis. A pathogenomics approach, by coupling of pan-genomic analysis of multiple isolates with sequencing of experimentally attenuated highly pathogenic Leptospira, has resulted in the functional inference of virulence factors. The global Leptospira Genome Project supported by the U.S. National Institute of Allergy and Infectious Diseases to which key scientific contributions have been made from the international leptospirosis research community has provided a new roadmap for comprehensive studies of Leptospira and leptospirosis well into the future. This review describes functional genomics approaches to apply the data generated by the Leptospira Genome Project towards deepening our knowledge of virulence factors of Leptospira using the emerging discipline of pathogenomics. View Full-Text. en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries Pathogens
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Pathogenomics en_US
dc.subject virulence en_US
dc.subject genomics en_US
dc.subject evolution en_US
dc.subject taxonomy en_US
dc.subject molecular epidemiology en_US
dc.subject systems biology en_US
dc.title Leptospiral pathogenomics en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/pathogens3020280
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.relation.issn 2076-0817


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