dc.contributor.author |
Barros, Nicolas |
|
dc.contributor.author |
Risco, Jorge |
|
dc.contributor.author |
Rodriguez, Carlos |
|
dc.contributor.author |
Sanchez, Cesar |
|
dc.contributor.author |
Gonzalez, Elsa |
|
dc.contributor.author |
Tanaka, Yuetsu |
|
dc.contributor.author |
Gotuzzo Herencia, José Eduardo |
|
dc.contributor.author |
White, A. Clinton |
|
dc.contributor.author |
Montes Delgado, Martin |
|
dc.date.accessioned |
2022-01-04T20:31:46Z |
|
dc.date.available |
2022-01-04T20:31:46Z |
|
dc.date.issued |
2013 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/10635 |
|
dc.description.abstract |
Human T lymphotropic virus type 1 (HTLV-1) infection displays variable clinical manifestations. These include inflammatory diseases such as HTLV-1 associated myelopathy (HAM) or immunosuppressive conditions such as Strongyloides stercoralis hyperinfection. The viral protein, Tax causes activation and proliferation of T cells. We hypothesize that the expression of Tax in T cell subsets characterizes the clinical manifestations of HTLV-1. To test this hypothesis, we measured T helper 1 effector cells and regulatory T cells (Tregs) among Tax expressing lymphocytes from peripheral blood mononuclear cells (PBMCs) of 32 HTLV-1 infected patients with HAM, with S. stercoralis co-infection or with asymptomatic infection. We observed increased ratios of Th1/Treg among Tax expressing lymphocytes in HAM patients. These data suggest that the expression of Tax among the different target cells may explain the variable presentation of HTLV-1. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Taylor and Francis |
|
dc.relation.ispartofseries |
Pathogens and Global Health |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
HTLV-1 |
en_US |
dc.subject |
Tax |
en_US |
dc.subject |
Immunology |
en_US |
dc.subject |
Regulatory T cells |
en_US |
dc.subject |
Th1 |
en_US |
dc.subject |
Foxp3 |
en_US |
dc.title |
CD4+ T cell subsets and Tax expression in HTLV-1 associated diseases |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1179/2047773213Y.0000000091 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.01.09 |
|
dc.relation.issn |
2047-7732 |
|