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CD4+ T cell subsets and Tax expression in HTLV-1 associated diseases

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dc.contributor.author Barros, Nicolas
dc.contributor.author Risco, Jorge
dc.contributor.author Rodriguez, Carlos
dc.contributor.author Sanchez, Cesar
dc.contributor.author Gonzalez, Elsa
dc.contributor.author Tanaka, Yuetsu
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author White, A. Clinton
dc.contributor.author Montes Delgado, Martin
dc.date.accessioned 2022-01-04T20:31:46Z
dc.date.available 2022-01-04T20:31:46Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10635
dc.description.abstract Human T lymphotropic virus type 1 (HTLV-1) infection displays variable clinical manifestations. These include inflammatory diseases such as HTLV-1 associated myelopathy (HAM) or immunosuppressive conditions such as Strongyloides stercoralis hyperinfection. The viral protein, Tax causes activation and proliferation of T cells. We hypothesize that the expression of Tax in T cell subsets characterizes the clinical manifestations of HTLV-1. To test this hypothesis, we measured T helper 1 effector cells and regulatory T cells (Tregs) among Tax expressing lymphocytes from peripheral blood mononuclear cells (PBMCs) of 32 HTLV-1 infected patients with HAM, with S. stercoralis co-infection or with asymptomatic infection. We observed increased ratios of Th1/Treg among Tax expressing lymphocytes in HAM patients. These data suggest that the expression of Tax among the different target cells may explain the variable presentation of HTLV-1. en_US
dc.language.iso eng
dc.publisher Taylor and Francis
dc.relation.ispartofseries Pathogens and Global Health
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject HTLV-1 en_US
dc.subject Tax en_US
dc.subject Immunology en_US
dc.subject Regulatory T cells en_US
dc.subject Th1 en_US
dc.subject Foxp3 en_US
dc.title CD4+ T cell subsets and Tax expression in HTLV-1 associated diseases en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1179/2047773213Y.0000000091
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.relation.issn 2047-7732


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