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dc.contributor.author | Barros, Nicolas | |
dc.contributor.author | Risco, Jorge | |
dc.contributor.author | Rodriguez, Carlos | |
dc.contributor.author | Sanchez, Cesar | |
dc.contributor.author | Gonzalez, Elsa | |
dc.contributor.author | Tanaka, Yuetsu | |
dc.contributor.author | Gotuzzo Herencia, José Eduardo | |
dc.contributor.author | White, A. Clinton | |
dc.contributor.author | Montes Delgado, Martin | |
dc.date.accessioned | 2022-01-04T20:31:46Z | |
dc.date.available | 2022-01-04T20:31:46Z | |
dc.date.issued | 2013 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/10635 | |
dc.description.abstract | Human T lymphotropic virus type 1 (HTLV-1) infection displays variable clinical manifestations. These include inflammatory diseases such as HTLV-1 associated myelopathy (HAM) or immunosuppressive conditions such as Strongyloides stercoralis hyperinfection. The viral protein, Tax causes activation and proliferation of T cells. We hypothesize that the expression of Tax in T cell subsets characterizes the clinical manifestations of HTLV-1. To test this hypothesis, we measured T helper 1 effector cells and regulatory T cells (Tregs) among Tax expressing lymphocytes from peripheral blood mononuclear cells (PBMCs) of 32 HTLV-1 infected patients with HAM, with S. stercoralis co-infection or with asymptomatic infection. We observed increased ratios of Th1/Treg among Tax expressing lymphocytes in HAM patients. These data suggest that the expression of Tax among the different target cells may explain the variable presentation of HTLV-1. | en_US |
dc.language.iso | eng | |
dc.publisher | Taylor and Francis | |
dc.relation.ispartofseries | Pathogens and Global Health | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | HTLV-1 | en_US |
dc.subject | Tax | en_US |
dc.subject | Immunology | en_US |
dc.subject | Regulatory T cells | en_US |
dc.subject | Th1 | en_US |
dc.subject | Foxp3 | en_US |
dc.title | CD4+ T cell subsets and Tax expression in HTLV-1 associated diseases | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1179/2047773213Y.0000000091 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.09 | |
dc.relation.issn | 2047-7732 |
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