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Infection of Domestic Dogs in Peru by Zoonotic Bartonella Species: A Cross-Sectional Prevalence Study of 219 Asymptomatic Dogs

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dc.contributor.author Diniz, Pedro Paulo V.P.
dc.contributor.author Morton, Bridget A.
dc.contributor.author Tngrian, Maryam
dc.contributor.author Kachani, Malika
dc.contributor.author Barrón, Eduardo A.
dc.contributor.author Gavidia, Cesar M.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Angulo, Noelia P.
dc.contributor.author Brenner, Elliott C.
dc.contributor.author Lerner, Richard
dc.contributor.author Chomel, Bruno B.
dc.date.accessioned 2022-01-04T20:31:47Z
dc.date.available 2022-01-04T20:31:47Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10657
dc.description.abstract Bartonella species are emerging infectious organisms transmitted by arthropods capable of causing long-lasting infection in mammalian hosts. Among over 30 species described from four continents to date, 15 are known to infect humans, with eight of these capable of infecting dogs as well. B. bacilliformis is the only species described infecting humans in Peru; however, several other Bartonella species were detected in small mammals, bats, ticks, and fleas in that country. The Objetive: of this study was to determine the serological and/or molecular prevalence of Bartonella species in asymptomatic dogs in Peru in order to indirectly evaluate the potential for human exposure to zoonotic Bartonella species. A convenient sample of 219 healthy dogs was obtained from five cities and three villages in Peru. EDTA-blood samples were collected from 205 dogs, whereas serum samples were available from 108 dogs. The EDTA-blood samples were screened by PCR followed by nucleotide sequencing for species identification. Antibodies against B. vinsonii berkhoffii and B. rochalimae were detected by IFA (cut-off of 1∶64). Bartonella DNA was detected in 21 of the 205 dogs (10%). Fifteen dogs were infected with B. rochalimae, while six dogs were infected with B. v. berkhoffii genotype III. Seropositivity for B. rochalimae was detected in 67 dogs (62%), and for B. v. berkhoffii in 43 (40%) of the 108 dogs. Reciprocal titers ≥1∶256 for B. rochalimae were detected in 19% of dogs, and for B. v. berkhoffii in 6.5% of dogs. This study identifies for the first time a population of dogs exposed to or infected with zoonotic Bartonella species, suggesting that domestic dogs may be the natural reservoir of these zoonotic organisms. Since dogs are epidemiological sentinels, Peruvian humans may be exposed to infections with B. rochalimae or B. v. berkhoffii. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animals en_US
dc.subject nucleotide sequence en_US
dc.subject Cross-Sectional Studies en_US
dc.subject Peru en_US
dc.subject prevalence en_US
dc.subject controlled study en_US
dc.subject polymerase chain reaction en_US
dc.subject Prevalence en_US
dc.subject animal experiment en_US
dc.subject animal model en_US
dc.subject disease carrier en_US
dc.subject DNA sequence en_US
dc.subject DNA, Bacterial en_US
dc.subject Molecular Sequence Data en_US
dc.subject phylogeny en_US
dc.subject genotype en_US
dc.subject Bartonella en_US
dc.subject zoonosis en_US
dc.subject Polymerase Chain Reaction en_US
dc.subject Asymptomatic Diseases en_US
dc.subject asymptomatic infection en_US
dc.subject serology en_US
dc.subject bacterium isolation en_US
dc.subject Bartonella bacilliformis en_US
dc.subject Bartonella Infections en_US
dc.subject bartonellosis en_US
dc.subject Sequence Analysis, DNA en_US
dc.subject Antibodies, Bacterial en_US
dc.subject antibody titer en_US
dc.subject Carrier State en_US
dc.subject bacterial transmission en_US
dc.subject Bartonella rochalimae en_US
dc.subject Bartonella vinsonii en_US
dc.subject dog en_US
dc.subject Dog Diseases en_US
dc.subject Dogs en_US
dc.subject Fluorescent Antibody Technique, Indirect en_US
dc.subject immunofluorescence test en_US
dc.title Infection of Domestic Dogs in Peru by Zoonotic Bartonella Species: A Cross-Sectional Prevalence Study of 219 Asymptomatic Dogs en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0002393
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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