Universidad Peruana Cayetano Heredia

Identification of Strain-Specific B-cell Epitopes in Trypanosoma cruzi Using Genome-Scale Epitope Prediction and High-Throughput Immunoscreening with Peptide Arrays

Identification of Strain-Specific B-cell Epitopes in Trypanosoma cruzi Using Genome-Scale Epitope Prediction and High-Throughput Immunoscreening with Peptide Arrays

de Oliveira Mendes, Tiago Antonio; Reis Cunha, Joao Luís; de Almeida Lourdes, Rodrigo; Rodrigues Luiz, Gabriela Flávia; Lemos, Lucas Dhom; dos Santos, Ana Rita Rocha; da Câmara, Antonia Cláudia Jácome; da Cunha Galvão, Lúcia Maria; Bern, Caryn; Gilman, Robert Hugh; Fujiwara, Ricardo Tostes; Gazzinelli, Ricardo Tostes; Bartholomeu, Daniella Castanheira
URI: https://hdl.handle.net/20.500.12866/10668
Fecha: 2013

Resumen:

The factors influencing variation in the clinical forms of Chagas disease have not been elucidated; however, it is likely that the genetics of both the host and the parasite are involved. Several studies have attempted to correlate the T. cruzi strains involved in infection with the clinical forms of the disease by using hemoculture and/or PCR-based genotyping of parasites from infected human tissues. However, both techniques have limitations that hamper the analysis of large numbers of samples. The goal of this work was to identify conserved and polymorphic linear B-cell epitopes of T. cruzi that could be used for serodiagnosis and serotyping of Chagas disease using ELISA.

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