dc.contributor.author |
Valencia, Braulio M. |
|
dc.contributor.author |
Miller, David |
|
dc.contributor.author |
Witzig, Richard S. |
|
dc.contributor.author |
Boggild, Andrea K. |
|
dc.contributor.author |
Llanos Cuentas, Elmer Alejandro |
|
dc.date.accessioned |
2022-01-04T20:31:48Z |
|
dc.date.available |
2022-01-04T20:31:48Z |
|
dc.date.issued |
2013 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/10669 |
|
dc.description.abstract |
Thermotherapy is an accepted alternative therapy for new-world cutaneous leishmaniasis, but current heat-delivery modalities are too costly to be made widely available to endemic populations. We adapted a low-cost heat pack named the HECT-CL device that delivers safe, reliable, and renewable conduction heat. 25 patients with cutaneous leishmaniasis completed treatment with the device at an initial temperature of 52°C±2°C for 3 minutes to each lesion, repeated daily for 7 days, and were followed up for 6 months by direct observation. The overall definitive clinical cure rate was 60%. Concurrently, 13 patients meeting minimally significant exclusion criteria received identical compassionate use treatment with a cumulative definitive cure rate of 68.4%, 75% for those who had experienced CL relapse after prior antimonial treatment. Therapy was well tolerated. Reversible second-degree burns occurred in two patients and no bacterial super-infections were observed. HECT-CL is a promising treatment and deserves further study to verify its safety and efficacy as adjuvant and mono- therapy. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Public Library of Science |
|
dc.relation.ispartofseries |
PLoS Neglected Tropical Diseases |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Humans |
en_US |
dc.subject |
Peru |
en_US |
dc.subject |
Treatment Outcome |
en_US |
dc.subject |
Pilot Projects |
en_US |
dc.subject |
Burns |
en_US |
dc.subject |
Costs and Cost Analysis |
en_US |
dc.subject |
Hyperthermia |
en_US |
dc.subject |
Leishmaniasis, Cutaneous |
en_US |
dc.title |
Novel Low-Cost Thermotherapy for Cutaneous Leishmaniasis in Peru |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1371/journal.pntd.0002196 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.03.06 |
|
dc.relation.issn |
1935-2735 |
|