Universidad Peruana Cayetano Heredia
Novel Low-Cost Thermotherapy for Cutaneous Leishmaniasis in Peru
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| dc.contributor.author | Valencia, Braulio M. | |
| dc.contributor.author | Miller, David | |
| dc.contributor.author | Witzig, Richard S. | |
| dc.contributor.author | Boggild, Andrea K. | |
| dc.contributor.author | Llanos Cuentas, Elmer Alejandro | |
| dc.date.accessioned | 2022-01-04T20:31:48Z | |
| dc.date.available | 2022-01-04T20:31:48Z | |
| dc.date.issued | 2013 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/10669 | |
| dc.description.abstract | Thermotherapy is an accepted alternative therapy for new-world cutaneous leishmaniasis, but current heat-delivery modalities are too costly to be made widely available to endemic populations. We adapted a low-cost heat pack named the HECT-CL device that delivers safe, reliable, and renewable conduction heat. 25 patients with cutaneous leishmaniasis completed treatment with the device at an initial temperature of 52°C±2°C for 3 minutes to each lesion, repeated daily for 7 days, and were followed up for 6 months by direct observation. The overall definitive clinical cure rate was 60%. Concurrently, 13 patients meeting minimally significant exclusion criteria received identical compassionate use treatment with a cumulative definitive cure rate of 68.4%, 75% for those who had experienced CL relapse after prior antimonial treatment. Therapy was well tolerated. Reversible second-degree burns occurred in two patients and no bacterial super-infections were observed. HECT-CL is a promising treatment and deserves further study to verify its safety and efficacy as adjuvant and mono- therapy. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Public Library of Science | |
| dc.relation.ispartofseries | PLoS Neglected Tropical Diseases | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Humans | en_US |
| dc.subject | Peru | en_US |
| dc.subject | Treatment Outcome | en_US |
| dc.subject | Pilot Projects | en_US |
| dc.subject | Burns | en_US |
| dc.subject | Costs and Cost Analysis | en_US |
| dc.subject | Hyperthermia | en_US |
| dc.subject | Leishmaniasis, Cutaneous | en_US |
| dc.title | Novel Low-Cost Thermotherapy for Cutaneous Leishmaniasis in Peru | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1371/journal.pntd.0002196 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.06 | |
| dc.relation.issn | 1935-2735 |
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