DSpace Repository

Gut Hormones, Appetite Suppression and Cachexia in Patients with Pulmonary TB

Show simple item record

dc.contributor.author Chang, Suzanne W.
dc.contributor.author Pan, William S.
dc.contributor.author Lozano Beltran, Daniel
dc.contributor.author Oleyda Baldelomar, Lizet
dc.contributor.author Solano, Marco Antonio
dc.contributor.author Tuero Ochoa, Iskra
dc.contributor.author Friedland, Jon S.
dc.contributor.author Torrico, Faustino
dc.contributor.author Gilman, Robert Hugh
dc.date.accessioned 2022-01-04T20:31:48Z
dc.date.available 2022-01-04T20:31:48Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10675
dc.description.abstract Background: Cachexia is a hallmark of pulmonary tuberculosis and is associated with poor prognosis. A better understanding of the mechanisms behind such weight loss could reveal targets for therapeutic intervention. The role of appetite-regulatory hormones in tuberculosis is unknown. Methods: and Findings: 41 subjects with newly-diagnosed pulmonary TB (cases) were compared to 82 healthy controls. We measured appetite, body mass index (BMI), % body fat (BF), plasma peptide YY (PYY), leptin, ghrelin, and resistin for all subjects. Measurements were taken at baseline for controls and at treatment days 0, 30, and 60 for cases. Baseline appetite, BMI, and BF were lower in cases than in controls and improved during treatment. PYY, ghrelin, and resistin were significantly elevated in cases and fell during treatment. Leptin was lower in cases and rose with treatment. Appetite was inversely related to PYY in cases. High pre-treatment PYY predicted reduced gains in appetite and BF. PYY was the strongest independent predictor of appetite in cases across all time points. Conclusions: Appetite-regulatory hormones are altered in TB patients. As hormones normalize during treatment, appetite is restored and nutritional status improves. High baseline PYY is an indicator of poor prognosis for improvement in appetite and nutrition during treatment. Wasting in TB patients may partly be mediated by upregulation of PYY with resulting appetite suppression. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject controlled study en_US
dc.subject lung tuberculosis en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Bolivia en_US
dc.subject Tuberculosis, Pulmonary en_US
dc.subject body mass en_US
dc.subject nutritional assessment en_US
dc.subject nutritional status en_US
dc.subject Nutritional Status en_US
dc.subject cohort analysis en_US
dc.subject prospective study en_US
dc.subject clinical assessment en_US
dc.subject Cohort Studies en_US
dc.subject article en_US
dc.subject prognosis en_US
dc.subject weight reduction en_US
dc.subject clinical article en_US
dc.subject malnutrition en_US
dc.subject body fat en_US
dc.subject Appetite en_US
dc.subject peptide YY en_US
dc.subject cachexia en_US
dc.subject Cachexia en_US
dc.subject decreased appetite en_US
dc.subject gastrointestinal hormone en_US
dc.subject Gastrointestinal Hormones en_US
dc.subject ghrelin en_US
dc.subject hormonal regulation en_US
dc.subject hormone blood level en_US
dc.subject leptin en_US
dc.subject resistin en_US
dc.title Gut Hormones, Appetite Suppression and Cachexia in Patients with Pulmonary TB en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0054564
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.27
dc.relation.issn 1932-6203


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics