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Epidemiology of Candidemia in Latin America: A Laboratory-Based Survey

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dc.contributor.author Nucci, Marcio
dc.contributor.author Queiroz-Telles, Flavio
dc.contributor.author Alvarado-Matute, Tito
dc.contributor.author Tiraboschi, Iris Nora
dc.contributor.author Cortes, Jorge
dc.contributor.author Zurita, Jeannete
dc.contributor.author Guzman-Blanco, Manuel
dc.contributor.author Santolaya, Maria Elena
dc.contributor.author Thompson, Luis
dc.contributor.author Sifuentes-Osornio, Jose
dc.contributor.author Echevarria Zarate, Juan Ignacio
dc.contributor.author Colombo, Arnaldo L.
dc.date.accessioned 2022-01-04T20:31:48Z
dc.date.available 2022-01-04T20:31:48Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10679
dc.description.abstract Background: The epidemiology of candidemia varies depending on the geographic region. Little is known about the epidemiology of candidemia in Latin America. Methods: We conducted a 24-month laboratory-based survey of candidemia in 20 centers of seven Latin American countries. Incidence rates were calculated and the epidemiology of candidemia was characterized. Results: Among 672 episodes of candidemia, 297 (44.2%) occurred in children (23.7% younger than 1 year), 36.2% in adults between 19 and 60 years old and 19.6% in elderly patients. The overall incidence was 1.18 cases per 1,000 admissions, and varied across countries, with the highest incidence in Colombia and the lowest in Chile. Candida albicans (37.6%), C. parapsilosis (26.5%) and C. tropicalis (17.6%) were the leading agents, with great variability in species distribution in the different countries. Most isolates were highly susceptible to fluconazole, voriconazole, amphotericin B and anidulafungin. Fluconazole was the most frequent agent used as primary treatment (65.8%), and the overall 30-day survival was 59.3%. Conclusions: This first large epidemiologic study of candidemia in Latin America showed a high incidence of candidemia, high percentage of children, typical species distribution, with C. albicans, C. parapsilosis and C. tropicalis accounting for the majority of episodes, and low resistance rates. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Latin America en_US
dc.subject major clinical study en_US
dc.subject outcome assessment en_US
dc.subject controlled study en_US
dc.subject disease association en_US
dc.subject incidence en_US
dc.subject prospective study en_US
dc.subject South and Central America en_US
dc.subject age distribution en_US
dc.subject amphotericin B en_US
dc.subject antifungal susceptibility en_US
dc.subject Candida en_US
dc.subject Candida albicans en_US
dc.subject Candida glabrata en_US
dc.subject Candida parapsilosis en_US
dc.subject Candida tropicalis en_US
dc.subject candidemia en_US
dc.subject fluconazole en_US
dc.subject Fluconazole en_US
dc.subject fungus identification en_US
dc.subject molecular epidemiology en_US
dc.subject voriconazole en_US
dc.subject Species Specificity en_US
dc.subject Epidemiological Monitoring en_US
dc.subject Candida krusei en_US
dc.subject fungus isolation en_US
dc.subject Candidemia en_US
dc.subject survival rate en_US
dc.subject anidulafungin en_US
dc.subject Pichia guilliermondii en_US
dc.subject survival time en_US
dc.subject Statistics, Nonparametric en_US
dc.subject organisms by geographical distribution en_US
dc.subject species distribution en_US
dc.title Epidemiology of Candidemia in Latin America: A Laboratory-Based Survey en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0059373
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.09
dc.relation.issn 1932-6203


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