Universidad Peruana Cayetano Heredia

Induced Sputum MMP-1, -3 & -8 Concentrations during Treatment of Tuberculosis

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dc.contributor.author Ugarte Gil, Cesar Augusto
dc.contributor.author Elkington, Paul
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Coronel, Jorge
dc.contributor.author Tezera, Liku B.
dc.contributor.author Bernabé Ortiz, Antonio
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Friedland, Jon S.
dc.contributor.author Moore, David Alexander James
dc.date.accessioned 2022-01-04T20:31:49Z
dc.date.available 2022-01-04T20:31:49Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10689
dc.description.abstract Introduction: Tuberculosis (TB) destroys lung tissues and this immunopathology is mediated in part by Matrix Metalloproteinases (MMPs). There are no data on the relationship between local tissue MMPs concentrations, anti-tuberculosis therapy and sputum conversion. Materials and Methods: Induced sputum was collected from 68 TB patients and 69 controls in a cross-sectional study. MMPs concentrations were measured by Luminex array, TIMP concentrations by ELISA and were correlated with a disease severity score (TBscore). 46 TB patients were then studied longitudinally at the 2nd, 8th week and end of treatment. Results: Sputum MMP-1,-2,-3,-8,-9 and TIMP-1 and -2 concentrations are increased in TB. Elevated MMP-1 and -3 concentrations are independently associated with higher TB severity scores (p<0.05). MMP-1, -3 and -8 concentrations decreased rapidly during treatment (p<0.05) whilst there was a transient increase in TIMP-1/2 concentrations at week 2. MMP-2, -8 and -9 and TIMP-2 concentrations were higher at TB diagnosis in patients who remain sputum culture positive at 2 weeks and MMP-3, -8 and TIMP-1 concentrations were higher in these patients at 2nd week of TB treatment. Conclusions: MMPs are elevated in TB patients and associate with disease severity. This matrix-degrading phenotype resolves rapidly with treatment. The MMP profile at presentation correlates with a delayed treatment response. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Cross-Sectional Studies en_US
dc.subject Humans en_US
dc.subject Case-Control Studies en_US
dc.subject Longitudinal Studies en_US
dc.subject Culture Techniques en_US
dc.subject Antitubercular Agents en_US
dc.subject Matrix Metalloproteinase 1 en_US
dc.subject Matrix Metalloproteinase 3 en_US
dc.subject Matrix Metalloproteinase 8 en_US
dc.subject Matrix Metalloproteinases, Secreted en_US
dc.subject Sputum en_US
dc.subject Tissue Inhibitor of Metalloproteinases en_US
dc.subject Tuberculosis en_US
dc.title Induced Sputum MMP-1, -3 & -8 Concentrations during Treatment of Tuberculosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0061333
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1932-6203


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