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Multiple genetic origins of histidine-rich protein 2 gene deletion in Plasmodium falciparum parasites from Peru

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dc.contributor.author Akinyi, Sheyla
dc.contributor.author Hayden, Tonya
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Torres Fajardo, Katherine Jessica
dc.contributor.author Bendezu, Jorge
dc.contributor.author Abdallah, Joseph F.
dc.contributor.author Griffing, Sean M.
dc.contributor.author Quezada, Wilmer M.
dc.contributor.author Arrospide, Nancy
dc.contributor.author De Oliveira, Alexandre Macedo
dc.contributor.author Lucas, Carmen
dc.contributor.author Magill, Alan J.
dc.contributor.author Bacon, David J.
dc.contributor.author Barnwell, John W.
dc.contributor.author Udhayakumar, Venkatachalam
dc.date.accessioned 2022-01-04T20:31:51Z
dc.date.available 2022-01-04T20:31:51Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10739
dc.description.abstract The majority of malaria rapid diagnostic tests (RDTs) detect Plasmodium falciparum histidine-rich protein 2 (PfHRP2), encoded by the pfhrp2 gene. Recently, P. falciparum isolates from Peru were found to lack pfhrp2 leading to false-negative RDT results. We hypothesized that pfhrp2-deleted parasites in Peru derived from a single genetic event. We evaluated the parasite population structure and pfhrp2 haplotype of samples collected between 1998 and 2005 using seven neutral and seven chromosome 8 microsatellite markers, respectively. Five distinct pfhrp2 haplotypes, corresponding to five neutral microsatellite-based clonal lineages, were detected in 1998-2001; pfhrp2 deletions occurred within four haplotypes. In 2003-2005, outcrossing among the parasite lineages resulted in eight population clusters that inherited the five pfhrp2 haplotypes seen previously and a new haplotype; pfhrp2 deletions occurred within four of these haplotypes. These findings indicate that the genetic origin of pfhrp2 deletion in Peru was not a single event, but likely occurred multiple times. en_US
dc.language.iso eng
dc.publisher Springer Nature
dc.relation.ispartofseries Scientific Reports
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animals en_US
dc.subject genetics en_US
dc.subject haplotype en_US
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject prevalence en_US
dc.subject phenotype en_US
dc.subject cluster analysis en_US
dc.subject Bayes theorem en_US
dc.subject Antigens, Protozoan en_US
dc.subject parasite antigen en_US
dc.subject Plasmodium falciparum en_US
dc.subject Haplotypes en_US
dc.subject protozoal protein en_US
dc.subject parasites en_US
dc.subject gene deletion en_US
dc.subject HRP 2 antigen en_US
dc.subject Plasmodium falciparum en_US
dc.subject microsatellite DNA en_US
dc.subject Microsatellite Repeats en_US
dc.subject parasite en_US
dc.title Multiple genetic origins of histidine-rich protein 2 gene deletion in Plasmodium falciparum parasites from Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/srep02797
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.07
dc.relation.issn 2045-2322


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