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Feasibility of Chlamydia trachomatis screening and treatment in pregnant women in Lima, Peru: a prospective study in two large urban hospitals

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dc.contributor.author Cabeza, Jeanne
dc.contributor.author García, Patricia J.
dc.contributor.author Segura, Eddy
dc.contributor.author García, Pedro
dc.contributor.author Escudero, Francisco
dc.contributor.author La Rosa, Sayda
dc.contributor.author León, Segundo
dc.contributor.author Klausner, Jeffrey D.
dc.date.accessioned 2022-01-04T20:31:51Z
dc.date.available 2022-01-04T20:31:51Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/10741
dc.description.abstract Objectives: Chlamydia trachomatis, which is asymptomatic in most women, causes significant adverse effects for pregnant women and neonates. No programmes conduct antenatal screening in Latin America. We determined chlamydia prevalence, feasibility and acceptability of chlamydia screening, and adherence to treatment in pregnant women in two urban public hospitals in Lima, Peru. Methods: We offered chlamydia screening using self-collected vaginal swabs to pregnant women ≥16 years of age during their first antenatal visit. Chlamydia-infected women were contacted within 14 days and asked to bring partners for counselling and directly observed therapy with oral azithromycin. Unaccompanied women received counselling, directly observed therapy, and azithromycin to take to partners. Test of cure was performed ≥3 weeks after treatment. Results We approached 640 women for the study and enrolled 600 (93.8%). Median age was 27.3 years (range 16–47), median lifetime partners 2.3 (range 1–50), and median gestational age 26.1 weeks (range 4–41). Chlamydia prevalence was 10% (95% CI 7.7% to 12.7%). Of 60 infected patients, 59 (98%) were treated with one dose of azithromycin. Fifty-two of 59 (88%) returned for test of cure, all of whom were treated successfully, with 46 (86%) achieving negative test of cure with one dose of azithromycin, and 6 (12%) after retreatment with a second dose. Conclusions C. trachomatis screening and treatment in pregnancy was feasible and highly acceptable in two urban hospitals in Peru. Chlamydia prevalence was high. Clinical trials to evaluate efficacy and cost-effectiveness of chlamydia screening, and treatment of pregnant women to prevent adverse pregnancy outcomes in low-resource settings, are warranted. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartof urn:issn:1472-3263
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Medication Adherence en_US
dc.subject Peru en_US
dc.subject Pregnancy en_US
dc.subject Treatment Outcome en_US
dc.subject Prospective Studies en_US
dc.subject Feasibility Studies en_US
dc.subject Cost-Benefit Analysis en_US
dc.subject Patient Acceptance of Health Care en_US
dc.subject Anti-Bacterial Agent en_US
dc.subject Azithromycin en_US
dc.subject Chlamydia Infections en_US
dc.subject Chlamydia Trachomatis en_US
dc.subject Hospitals en_US
dc.subject Mass Screening en_US
dc.subject Screening en_US
dc.subject Vagina en_US
dc.title Feasibility of Chlamydia trachomatis screening and treatment in pregnant women in Lima, Peru: a prospective study in two large urban hospitals en_US
dc.type info:eu-repo/semantics/article
dc.identifier.journal Sexually Transmitted Infections
dc.identifier.doi https://doi.org/10.1136/sextrans-2014-051531
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.15

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