Human host-derived cytokines associated with Plasmodium vivax transmission from acute malaria patients to Anopheles darlingi mosquitoes in the Peruvian Amazon

Vinetz, Joseph Michael; Abeles, Shira R.; Chuquiyauri, Raul; Tong, Chuquiyauri

dc.contributor.author	Abeles, Shira R.
dc.contributor.author	Chuquiyauri, Raul
dc.contributor.author	Tong, Chuquiyauri
dc.contributor.author	Vinetz, Joseph Michael
dc.date.accessioned	2022-01-04T20:33:20Z
dc.date.available	2022-01-04T20:33:20Z
dc.date.issued	2013
dc.identifier.uri	https://hdl.handle.net/20.500.12866/10761
dc.description.abstract	Infection of mosquitoes by humans is not always successful in the setting of patent gametocytemia. This study tested the hypothesis that pro- or anti-inflammatory cytokines are associated with transmission of Plasmodium vivax to Anopheles darlingi mosquitoes in experimental infection. Blood from adults with acute, non-severe P. vivax malaria was fed to laboratory-reared F1 An. darlingi mosquitoes. A panel of cytokines at the time of mosquito infection was assessed in patient sera and levels compared among subjects who did and did not infect mosquitoes. Overall, blood from 43 of 99 (43%) subjects led to mosquito infection as shown by oocyst counts. Levels of IL-10, IL-6, TNF-α, and IFN-γ were significantly elevated in vivax infection and normalized 3 weeks later. The anti-inflammatory cytokine IL-10 was significantly higher in nontransmitters compared with top transmitters but was not in TNF-α and IFN-γ. The IL-10 elevation during acute malaria was associated with P. vivax transmission blocking.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Animals	en_US
dc.subject	Humans	en_US
dc.subject	major clinical study	en_US
dc.subject	Peru	en_US
dc.subject	adolescent	en_US
dc.subject	interleukin 4	en_US
dc.subject	interleukin 5	en_US
dc.subject	blood	en_US
dc.subject	clinical assessment	en_US
dc.subject	Cytokines	en_US
dc.subject	fever	en_US
dc.subject	disease transmission	en_US
dc.subject	follow up	en_US
dc.subject	Malaria, Vivax	en_US
dc.subject	Parasitemia	en_US
dc.subject	Plasmodium vivax	en_US
dc.subject	Plasmodium vivax malaria	en_US
dc.subject	Host-Parasite Interactions	en_US
dc.subject	Insect Vectors	en_US
dc.subject	cytokine response	en_US
dc.subject	gamma interferon	en_US
dc.subject	Interferon-gamma	en_US
dc.subject	interleukin 10	en_US
dc.subject	Interleukin-10	en_US
dc.subject	tumor necrosis factor alpha	en_US
dc.subject	Tumor Necrosis Factor-alpha	en_US
dc.subject	Malaria	en_US
dc.subject	Anopheles	en_US
dc.subject	Anopheles darlingi	en_US
dc.subject	oocyst	en_US
dc.subject	interleukin 6	en_US
dc.subject	Interleukin-6	en_US
dc.subject	interleukin 1beta	en_US
dc.subject	interleukin 8	en_US
dc.subject	interleukin 2	en_US
dc.subject	granulocyte macrophage colony stimulating factor	en_US
dc.title	Human host-derived cytokines associated with Plasmodium vivax transmission from acute malaria patients to Anopheles darlingi mosquitoes in the Peruvian Amazon	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.12-0752
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645