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Microgeographical differences of Plasmodium vivax relapse and re-infection in the Peruvian Amazon

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dc.contributor.author Chuquiyauri, Raul
dc.contributor.author Peñataro, Pablo
dc.contributor.author Brouwer, Kimberly C.
dc.contributor.author Fasabi, Manuel
dc.contributor.author Calderón Sánchez, Maritza Mercedes
dc.contributor.author Torres, Sonia
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Kosek, Margaret
dc.contributor.author Vinetz, Joseph Michael
dc.date.accessioned 2022-01-04T20:33:21Z
dc.date.available 2022-01-04T20:33:21Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10768
dc.description.abstract To determine the magnitude of Plasmodium vivax relapsing malaria in rural Amazonia, we carried out a study in four sites in northeastern Peru. Polymerase chain reaction-restriction fragment length polymorphism of PvMSP-3α and tandem repeat (TR) markers were compared for their ability to distinguish relapse versus reinfection. Of 1,507 subjects with P. vivax malaria, 354 developed > 1 episode during the study; 97 of 354 (27.5%) were defined as relapse using Pvmsp-3α alone. The addition of TR polymorphism analysis significantly reduced the number of definitively defined relapses to 26 of 354 (7.4%) (P < 0.05). Multivariate logistic regression modeling showed that the probability of having > 1 infection was associated with the following: subjects in Mazan (odds ratio [OR] = 2.56; 95% confidence interval [CI] 1.87, 3.51), 15–44 years of age (OR = 1.49; 95% CI 1.03, 2.15), traveling for job purposes (OR = 1.45; 95%CI 1.03, 2.06), and travel within past month (OR = 1.46; 95% CI 1.0, 2.14). The high discriminatory capacity of the molecular tools shown here is useful for understanding the micro-geography of malaria transmission. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Geographical variation (species) en_US
dc.subject major clinical study en_US
dc.subject Peru en_US
dc.subject polymerase chain reaction en_US
dc.subject disease association en_US
dc.subject Time Factors en_US
dc.subject DNA, Protozoan en_US
dc.subject disease transmission en_US
dc.subject Plasmodium vivax en_US
dc.subject Plasmodium vivax malaria en_US
dc.subject Polymerase Chain Reaction en_US
dc.subject Genetic Markers en_US
dc.subject Genotype en_US
dc.subject Molecular Epidemiology en_US
dc.subject probability en_US
dc.subject Recurrence en_US
dc.subject Polymorphism, Genetic en_US
dc.subject Protozoan Proteins en_US
dc.subject chloroquine plus primaquine en_US
dc.subject travel en_US
dc.subject reinfection en_US
dc.subject Polymorphism, Restriction Fragment Length en_US
dc.subject restriction fragment length polymorphism en_US
dc.subject tandem repeat en_US
dc.title Microgeographical differences of Plasmodium vivax relapse and re-infection in the Peruvian Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.13-0060
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1476-1645


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