Microgeographical differences of Plasmodium vivax relapse and re-infection in the Peruvian Amazon

Vinetz, Joseph Michael; Brouwer, Kimberly C.; Calderón Sánchez, Maritza Mercedes; Gilman, Robert Hugh; Chuquiyauri, Raul; Torres, Sonia; Peñataro, Pablo; Fasabi, Manuel; Kosek, Margaret

dc.contributor.author	Chuquiyauri, Raul
dc.contributor.author	Peñataro, Pablo
dc.contributor.author	Brouwer, Kimberly C.
dc.contributor.author	Fasabi, Manuel
dc.contributor.author	Calderón Sánchez, Maritza Mercedes
dc.contributor.author	Torres, Sonia
dc.contributor.author	Gilman, Robert Hugh
dc.contributor.author	Kosek, Margaret
dc.contributor.author	Vinetz, Joseph Michael
dc.date.accessioned	2022-01-04T20:33:21Z
dc.date.available	2022-01-04T20:33:21Z
dc.date.issued	2013
dc.identifier.uri	https://hdl.handle.net/20.500.12866/10768
dc.description.abstract	To determine the magnitude of Plasmodium vivax relapsing malaria in rural Amazonia, we carried out a study in four sites in northeastern Peru. Polymerase chain reaction-restriction fragment length polymorphism of PvMSP-3α and tandem repeat (TR) markers were compared for their ability to distinguish relapse versus reinfection. Of 1,507 subjects with P. vivax malaria, 354 developed > 1 episode during the study; 97 of 354 (27.5%) were defined as relapse using Pvmsp-3α alone. The addition of TR polymorphism analysis significantly reduced the number of definitively defined relapses to 26 of 354 (7.4%) (P < 0.05). Multivariate logistic regression modeling showed that the probability of having > 1 infection was associated with the following: subjects in Mazan (odds ratio [OR] = 2.56; 95% confidence interval [CI] 1.87, 3.51), 15–44 years of age (OR = 1.49; 95% CI 1.03, 2.15), traveling for job purposes (OR = 1.45; 95%CI 1.03, 2.06), and travel within past month (OR = 1.46; 95% CI 1.0, 2.14). The high discriminatory capacity of the molecular tools shown here is useful for understanding the micro-geography of malaria transmission.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Geographical variation (species)	en_US
dc.subject	major clinical study	en_US
dc.subject	Peru	en_US
dc.subject	polymerase chain reaction	en_US
dc.subject	disease association	en_US
dc.subject	Time Factors	en_US
dc.subject	DNA, Protozoan	en_US
dc.subject	disease transmission	en_US
dc.subject	Plasmodium vivax	en_US
dc.subject	Plasmodium vivax malaria	en_US
dc.subject	Polymerase Chain Reaction	en_US
dc.subject	Genetic Markers	en_US
dc.subject	Genotype	en_US
dc.subject	Molecular Epidemiology	en_US
dc.subject	probability	en_US
dc.subject	Recurrence	en_US
dc.subject	Polymorphism, Genetic	en_US
dc.subject	Protozoan Proteins	en_US
dc.subject	chloroquine plus primaquine	en_US
dc.subject	travel	en_US
dc.subject	reinfection	en_US
dc.subject	Polymorphism, Restriction Fragment Length	en_US
dc.subject	restriction fragment length polymorphism	en_US
dc.subject	tandem repeat	en_US
dc.title	Microgeographical differences of Plasmodium vivax relapse and re-infection in the Peruvian Amazon	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.13-0060
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645