dc.contributor.author |
Gonzales Rengifo, Gustavo Francisco |
|
dc.contributor.author |
Gonzales Arimborgo, Carla Jeannine |
|
dc.contributor.author |
Villegas, Leon |
|
dc.date.accessioned |
2022-01-04T20:33:21Z |
|
dc.date.available |
2022-01-04T20:33:21Z |
|
dc.date.issued |
2014 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/10774 |
|
dc.description.abstract |
Context: Sacha inchi (Plukenetia volubilis L.) is a potential oilseed crop because it is rich in α-linolenic acid (ALA) (omega-3 fatty acid). Objective: To evaluate the exposure of fatty acids after a single oral administration of sacha inchi or sunflower oil in healthy volunteers. Material and methods: Plasma fatty acids concentrations were assayed by Gas Chromatography with Flame Ionization Detector in 18 adult subjects. After fasting, blood samples were obtained at 0, 0.5, 1, 2, 4, 8 and 24 h after ingestion of 10 or 15 ml of sacha inchi oil or sunflower oil. Results: The proportion ALA/linoleic acid was 1.37 in sacha inchi oil and 0.01 in sunflower oil. ALA, lauric acid, palmitic acid, linolelaidic acid, cis-8,11,14-eicosatrienoic acid, cis-13,16-docosadienoic acid and cis-4,7,10,13,16,19-docosahexaenoic acid (DHA) levels changed over time after sacha inchi oil ingestion but not with sunflower oil. The time at maximal concentration (tmax) for ALA was 2 h after sacha inchi oil ingestion. No ALA in plasma was observed after sunflower oil consumption. The maximal concentration of ALA was 2.84 ± 0.36 mg/ml in women and 0.94 ± 0.57 mg/ml in men, p < 0.05, whereas maximal concentration of DHA was 2.60 ± 0.84 mg/ml in women and 1.00 ± 0.38 mg/ml in men (p > 0.05). There is a trend for higher plasma ALA levels with 15 ml sacha inchi oil. After 2 h of consumption, plasma delta triacylglycerol were reduced with sunflower oil but slightly increased with sacha inchi oil. A reduction in plasma delta triacylglycerol-rich lipoprotein cholesterol was observed with both oils. Conclusion: Consumption of sacha inchi oil increased ALA and DHA in plasma. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Taylor and Francis |
|
dc.relation.ispartofseries |
Toxicology Mechanisms and Methods |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Fatty acids |
en_US |
dc.subject |
PUFA |
en_US |
dc.subject |
linolenic acid |
en_US |
dc.subject |
linoleic acid |
en_US |
dc.subject |
DHA |
en_US |
dc.title |
Exposure of fatty acids after a single oral administration of sacha inchi (Plukenetia volubilis L ) and sunflower oil in human adult subjects |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.3109/15376516.2013.850566 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.01.07 |
|
dc.relation.issn |
1537-6524 |
|