Universidad Peruana Cayetano Heredia
Exposure of fatty acids after a single oral administration of sacha inchi (Plukenetia volubilis L ) and sunflower oil in human adult subjects
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| dc.contributor.author | Gonzales Rengifo, Gustavo Francisco | |
| dc.contributor.author | Gonzales Arimborgo, Carla Jeannine | |
| dc.contributor.author | Villegas, Leon | |
| dc.date.accessioned | 2022-01-04T20:33:21Z | |
| dc.date.available | 2022-01-04T20:33:21Z | |
| dc.date.issued | 2014 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/10774 | |
| dc.description.abstract | Context: Sacha inchi (Plukenetia volubilis L.) is a potential oilseed crop because it is rich in α-linolenic acid (ALA) (omega-3 fatty acid). Objective: To evaluate the exposure of fatty acids after a single oral administration of sacha inchi or sunflower oil in healthy volunteers. Material and methods: Plasma fatty acids concentrations were assayed by Gas Chromatography with Flame Ionization Detector in 18 adult subjects. After fasting, blood samples were obtained at 0, 0.5, 1, 2, 4, 8 and 24 h after ingestion of 10 or 15 ml of sacha inchi oil or sunflower oil. Results: The proportion ALA/linoleic acid was 1.37 in sacha inchi oil and 0.01 in sunflower oil. ALA, lauric acid, palmitic acid, linolelaidic acid, cis-8,11,14-eicosatrienoic acid, cis-13,16-docosadienoic acid and cis-4,7,10,13,16,19-docosahexaenoic acid (DHA) levels changed over time after sacha inchi oil ingestion but not with sunflower oil. The time at maximal concentration (tmax) for ALA was 2 h after sacha inchi oil ingestion. No ALA in plasma was observed after sunflower oil consumption. The maximal concentration of ALA was 2.84 ± 0.36 mg/ml in women and 0.94 ± 0.57 mg/ml in men, p < 0.05, whereas maximal concentration of DHA was 2.60 ± 0.84 mg/ml in women and 1.00 ± 0.38 mg/ml in men (p > 0.05). There is a trend for higher plasma ALA levels with 15 ml sacha inchi oil. After 2 h of consumption, plasma delta triacylglycerol were reduced with sunflower oil but slightly increased with sacha inchi oil. A reduction in plasma delta triacylglycerol-rich lipoprotein cholesterol was observed with both oils. Conclusion: Consumption of sacha inchi oil increased ALA and DHA in plasma. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Taylor and Francis | |
| dc.relation.ispartofseries | Toxicology Mechanisms and Methods | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Fatty acids | en_US |
| dc.subject | PUFA | en_US |
| dc.subject | linolenic acid | en_US |
| dc.subject | linoleic acid | en_US |
| dc.subject | DHA | en_US |
| dc.title | Exposure of fatty acids after a single oral administration of sacha inchi (Plukenetia volubilis L ) and sunflower oil in human adult subjects | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.3109/15376516.2013.850566 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.07 | |
| dc.relation.issn | 1537-6524 |
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