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dc.contributor.author | Battaglioli, T. | |
dc.contributor.author | Soto, A. | |
dc.contributor.author | Agapito, J. | |
dc.contributor.author | Acurio, V. | |
dc.contributor.author | Van der Stuyft, P. | |
dc.date.accessioned | 2022-01-04T20:33:21Z | |
dc.date.available | 2022-01-04T20:33:21Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/10787 | |
dc.description.abstract | Objectives: To compare the performance of liquid culture on simple Middlebrook 7H9 to the one of manual mycobacterial growth indicator tube (MGIT) and solid culture on Ogawa for the diagnosis of smear-negative tuberculosis (SN-TB) in a high-burden, resource-constrained setting. Methods: Sputum samples from patients with clinical suspicion of SN-PTB admitted to two-third-level hospitals in Lima between September 2005 and May 2008 were cultured in parallel on simple Middlebrook 7H9, manual MGIT and Ogawa. A case of SN-TB was defined as one with a positive culture in any medium. Results: Among samples from 542 patients, 151 (28%) cases of SN-TB were identified. The sensitivity of Middlebrook 7H9 (0.76, 95% CI 0.69–0.83) was not substantially different from that of MGIT (0.85, 95% CI 0.79–0.91). Ogawa had the lowest sensitivity (0.63, 95% CI 0.55–0.71). The median turnaround time was similar for both liquid media (18 days), and it was shorter than that of Ogawa (30 days). Conclusions: Culture on simple Middlebrook 7H9 performs almost as well as MGIT, at a probably more affordable cost. Further studies on the cost-effectiveness of this overlooked technique should be performed. | en_US |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartofseries | Tropical Medicine and International Health | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Middlebrook 7H9 | en_US |
dc.subject | mycobacterial growth indicator tube | en_US |
dc.subject | Ogawa | en_US |
dc.subject | Mycobacterium tuberculosis | en_US |
dc.subject | diagnosis | en_US |
dc.subject | smear-negative tuberculosis | en_US |
dc.title | Manual liquid culture on simple Middlebrook 7H9 or MGIT for the diagnosis of smear-negative pulmonary tuberculosis | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1111/tmi.12384 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.06 | |
dc.relation.issn | 1365-3156 |
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